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Neuroprotective and Anti-inflammatory Ditetrahydrofuran-Containing Diarylheptanoids from Tacca chantrieri

文献类型：期刊论文

作者Yang, Yue3,4,5; Gong, Qi6; Wang, Wei6; Mao, Ying-Le3,4; Wang, Xiao-Rong1,7; Yao, Sheng3,4; Zhang, Hai-Yan6; Tang, Chunping3,4; Ye, Yang2,3,4
刊名JOURNAL OF NATURAL PRODUCTS
出版日期2020-12-24
卷号83期号:12页码:3681-3688
ISSN号0163-3864
DOI10.1021/acs.jnatprod.0c00901
通讯作者Tang, Chunping(tangcp@simm.ac.cn) ; Ye, Yang(yye@mail.shcnc.ac.cn)
英文摘要Three new dimeric diarylheptanoids, taccachanfurans A-C (1-3), a new monomeric diarylheptanoid, taccachannoid A (4), and four known diarylheptanoids (5-8) were isolated from the EtOH extract of the rhizomes of Tacca chantrieri. Their structures were established on the basis of comprehensive spectroscopic data analysis. The absolute configuration of taccachanfuran A (1) was confirmed by single-crystal X-ray diffraction. All the diarylheptanoid dimers contain a ditetrahydrofuran moiety, which has not been described previously for diarylheptanoid compounds. A plausible biosynthetic pathway for the diarylheptanoid dimers is proposed. Compounds 2-4 showed significant neuroprotective activity against A beta(25-35)-induced damage in SH-SY5Y cells at the concentrations of 10 and 1 mu M. Compounds 3, 4, 6, 7, and 8 showed anti-inflammatory activity in LPS-stimulated murine microglial BV-2 cells at the concentrations of 10 and 1 mu M.
WOS关键词CURCUMA-COMOSA ; RHIZOMES ; CONSTITUENTS ; PROTEIN ; CELLS
资助项目National Science and Technology Major Project[2019ZX09201004-003-042] ; National Natural Science Foundation of China[21920102003] ; National Natural Science Foundation of China[81903485]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000603402900022
源URL[http://119.78.100.183/handle/2S10ELR8/296130]  
专题新药研究国家重点实验室
通讯作者Tang, Chunping; Ye, Yang
作者单位1.Xishuangbanna Res Inst Nationality Med, Jinghong 666100, Xishuangbanna D, Peoples R China
2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
7.Xishuangbanna Hosp Tradit Dai Med, Jinghong 666100, Xishuangbanna D, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Yue,Gong, Qi,Wang, Wei,et al. Neuroprotective and Anti-inflammatory Ditetrahydrofuran-Containing Diarylheptanoids from Tacca chantrieri[J]. JOURNAL OF NATURAL PRODUCTS,2020,83(12):3681-3688.
APA Yang, Yue.,Gong, Qi.,Wang, Wei.,Mao, Ying-Le.,Wang, Xiao-Rong.,...&Ye, Yang.(2020).Neuroprotective and Anti-inflammatory Ditetrahydrofuran-Containing Diarylheptanoids from Tacca chantrieri.JOURNAL OF NATURAL PRODUCTS,83(12),3681-3688.
MLA Yang, Yue,et al."Neuroprotective and Anti-inflammatory Ditetrahydrofuran-Containing Diarylheptanoids from Tacca chantrieri".JOURNAL OF NATURAL PRODUCTS 83.12(2020):3681-3688.

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来源：上海药物研究所

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