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Phospholipid membrane-decorated deep-penetrated nanocatalase relieve tumor hypoxia to enhance chemo-photodynamic therapy

文献类型：期刊论文

作者Yin, Junjing1,2,3; Cao, Haiqiang1,3; Wang, Hong1,3; Sun, Kaoxiang2; Li, Yaping1,2,3; Zhang, Zhiwen1,3,4
刊名ACTA PHARMACEUTICA SINICA B
出版日期2020-11-01
卷号10期号:11页码:2246-2257
ISSN号2211-3835
关键词Photodynamic therapy Tumor hypoxia Catalase Tumor penetration Drug delivery Nanoparticle Tumor targeting Cancer metastasis Cancer therapy
DOI10.1016/j.apsb.2020.06.004
通讯作者Sun, Kaoxiang(sunkaoxiang@luye.com) ; Zhang, Zhiwen(zwzhang0125@simm.ac.cn)
英文摘要Hypoxia is a serious impediment to current treatments of many malignant tumors. Catalase, an antioxidant enzyme, is capable of decomposing endogenous hydrogen peroxide (H2O2) into oxygen for tumor reoxygenation, but suffered from in vivo instability and limited delivery to deep interior hypoxic regions in tumor. Herein, a deep-penetrated nanocatalase-loading DiIC18 (5, DiD) and soravtansine (Cat@PDS) were provided by coating catalase nanoparticles with PEGylated phospholipids membrane, stimulating the structure and function of erythrocytes to relieve tumor hypoxia for enhanced chemophotodynamic therapy. After intravenous administration, Cat@PDS preferentially accumulated at tumor sites, flexibly penetrated into the interior regions of tumor mass and remarkably relieved the hypoxic status in tumor. Notably, the Cat@PDS thorn laser treatment produced striking inhibition of tumor growth and resulted in a 97.2% suppression of lung metastasis. Thus, the phospholipids membrane-coated nanocatalase system represents an encouraging nanoplatform to relieve tumor hypoxia and synergize the chemophotodynamic cancer therapy. (C) 2020 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
WOS关键词CATALASE ACTIVITY ; BREAST-CANCER ; NANOPARTICLES ; AVAILABILITY ; ANGIOGENESIS ; NANOPLATFORM ; RADIOTHERAPY ; OXYGENATION ; RESISTANCE ; EFFICIENT
资助项目Strategic Priority Research Program of CAS (China)[XDA12050307] ; National Natural Science Foundation of China[31771092] ; National Natural Science Foundation of China[81803444] ; Youth Innovation Promotion Association of CAS ; Fudan-SIMM Joint Research Fund (China)[FU-SIMM20182005]
WOS研究方向Pharmacology & Pharmacy
语种英语
出版者INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
WOS记录号WOS:000595499500015
源URL[http://119.78.100.183/handle/2S10ELR8/296192]  
专题新药研究国家重点实验室
通讯作者Sun, Kaoxiang; Zhang, Zhiwen
作者单位1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China
4.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Peoples R China
推荐引用方式
GB/T 7714		 Yin, Junjing,Cao, Haiqiang,Wang, Hong,et al. Phospholipid membrane-decorated deep-penetrated nanocatalase relieve tumor hypoxia to enhance chemo-photodynamic therapy[J]. ACTA PHARMACEUTICA SINICA B,2020,10(11):2246-2257.
APA Yin, Junjing,Cao, Haiqiang,Wang, Hong,Sun, Kaoxiang,Li, Yaping,&Zhang, Zhiwen.(2020).Phospholipid membrane-decorated deep-penetrated nanocatalase relieve tumor hypoxia to enhance chemo-photodynamic therapy.ACTA PHARMACEUTICA SINICA B,10(11),2246-2257.
MLA Yin, Junjing,et al."Phospholipid membrane-decorated deep-penetrated nanocatalase relieve tumor hypoxia to enhance chemo-photodynamic therapy".ACTA PHARMACEUTICA SINICA B 10.11(2020):2246-2257.

入库方式： OAI收割

来源：上海药物研究所

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