Diterpene Biosynthesis in Catenulispora acidiphila: On the Mechanism of Catenul-14-en-6-ol Synthase
文献类型：期刊论文
| 作者 | Li, Geng1,2,3; Guo, Yue-Wei1,3 ; Dickschat, Jeroen S.2
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| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2020-12-10 |
| 页码 | 6 |
| ISSN号 | 1433-7851 |
| 关键词 | biosynthesis enzyme mechanisms isotopes substrate analogues terpenoids |
| DOI | 10.1002/anie.202014180 |
| 通讯作者 | Guo, Yue-Wei(ywguo@simm.ac.cn) ; Dickschat, Jeroen S.(dickschat@uni-bonn.de) |
| 英文摘要 | A new diterpene synthase from the actinomycete Catenulispora acidiphila was identified and the structures of its products were elucidated, including the absolute configurations by an enantioselective deuteration approach. The mechanism of the cationic terpene cyclisation cascade was deeply studied through the use of isotopically labelled substrates and of substrate analogues with partially blocked reactivity, resulting in derailment products that gave further insights into the intermediates along the cascade. Their chemistry was studied, leading to the biomimetic synthesis of a diterpenoid analogue of a brominated sesquiterpene known from the red seaweed Laurencia microcladia. |
| WOS关键词 | TERPENE SYNTHASES ; DYOTROPIC REARRANGEMENTS ; TERMITE SOLDIER ; CYCLIZATION ; CYCLASES ; SESQUITERPENE ; GERMACRENE ; DI |
| 资助项目 | DFG[DI1536/7-2] ; Natural Science foundation of China[81991521] ; Natural Science foundation of China[81520108028] ; CAS-DAAD Doctoral Joint Scholarship Program |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000597247900001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/296195]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Guo, Yue-Wei; Dickschat, Jeroen S. |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Univ Bonn, Kekule Inst Organ Chem & Biochem, Gerhard Domagk Str 1, D-53121 Bonn, Germany 3.Chinese Acad Sci, Inst Mat Med, State Key Lab Drug Res Shanghai, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Geng,Guo, Yue-Wei,Dickschat, Jeroen S.. Diterpene Biosynthesis in Catenulispora acidiphila: On the Mechanism of Catenul-14-en-6-ol Synthase[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020:6. |
| APA | Li, Geng,Guo, Yue-Wei,&Dickschat, Jeroen S..(2020).Diterpene Biosynthesis in Catenulispora acidiphila: On the Mechanism of Catenul-14-en-6-ol Synthase.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,6. |
| MLA | Li, Geng,et al."Diterpene Biosynthesis in Catenulispora acidiphila: On the Mechanism of Catenul-14-en-6-ol Synthase".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020):6. |
入库方式： OAI收割
来源：上海药物研究所
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