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New lobane-type diterpenoids from the Xisha soft coral Sinularia polydactyla

文献类型：期刊论文

作者Ye Fei1,2; Chen Zi-Hui1,2; Gu Yu-Cheng4; Guo Yue-Wei1,2,3; Li Xu-Wen1,2,3
刊名CHINESE JOURNAL OF NATURAL MEDICINES
出版日期2020-11-01
卷号18期号:11页码:839-843
关键词Soft coral Sinularia polydactyla Lobane Diterpenes
ISSN号2095-6975
DOI10.1016/S1875-5364(20)60025-5
通讯作者Guo Yue-Wei(ywguo@simm.ac.cn) ; Li Xu-Wen(xwli@simm.ac.cn)
英文摘要Lobane-type diterpenoids are not frequently discovered from marine soft corals. In this paper, three new lobane type diterpenes, 13-methoxyloba-8,10,15(16),17(18)-tetraene (1), 8,10,13(15)Z,16E-lobatetraene (2) and 19-hydroxy-lobatetraene (3), and a new natural compound, 17,18-epoxyloba-16-acetoxy-8,10,13(15)-trien (4), co-occurring with a known related diterpenoid, 18-methoxyloba-8,10,13(15),16(17)-tetraene (5), were isolated from the South China Sea soft coral Sinularia polydactyla. The structures of new compounds were determined by extensive spectroscopic analysis and by comparison with those reported in the literature. In bioassay, all the isolates were inactive on antibacterial, PTP1B inhibitory, and immunological activities. This study increased the chemical diversity of marine diterpenoids.
WOS关键词POLYHYDROXYLATED STEROIDS
资助项目National Key Research and Development Program of China[2018YFC-0310903] ; Natural Science Foundation of China[81991521] ; Natural Science Foundation of China[21672230] ; Natural Science Foundation of China[81520108028] ; NSFC/CNRS Joint Project[81811530284] ; SKLDR/SIMM Project[SIMM1903ZZ-04] ; Shanghai Rising-Star Program[20QA1411100] ; SA-SIBS Scholarship Program ; Syngenta-SIMM-PhD Studentship Project
WOS研究方向Integrative & Complementary Medicine ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000597313300006
出版者CHINESE JOURNAL NATURAL MEDICINES
源URL[http://119.78.100.183/handle/2S10ELR8/296204]  
专题新药研究国家重点实验室
通讯作者Guo Yue-Wei; Li Xu-Wen
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Open Studio Druggabil Res Marine Nat Prod, Qingdao 266237, Peoples R China
4.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England
推荐引用方式
GB/T 7714		 Ye Fei,Chen Zi-Hui,Gu Yu-Cheng,et al. New lobane-type diterpenoids from the Xisha soft coral Sinularia polydactyla[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2020,18(11):839-843.
APA Ye Fei,Chen Zi-Hui,Gu Yu-Cheng,Guo Yue-Wei,&Li Xu-Wen.(2020).New lobane-type diterpenoids from the Xisha soft coral Sinularia polydactyla.CHINESE JOURNAL OF NATURAL MEDICINES,18(11),839-843.
MLA Ye Fei,et al."New lobane-type diterpenoids from the Xisha soft coral Sinularia polydactyla".CHINESE JOURNAL OF NATURAL MEDICINES 18.11(2020):839-843.

入库方式： OAI收割

来源：上海药物研究所

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