Neonatal exposure to ketamine disrupts developmental synapse unsilencing and predisposes adult mice for stressor-evoked anxiety
文献类型：期刊论文
| 作者 | Zhang, Xiaoyun2,3; Kong, Yue1,2,3; He, Guiqin3; Zhou, Zikai1,3,4 |
| 刊名 | NEUROPHARMACOLOGY
 |
| 出版日期 | 2020-12-01 |
| 卷号 | 180页码:12 |
| 关键词 | Stress Anxiety Silent synapse Long-term potentiation Anesthesia |
| ISSN号 | 0028-3908 |
| DOI | 10.1016/j.neuropharm.2020.108300 |
| 通讯作者 | Zhang, Xiaoyun(xiaoyun_zhang@seu.edu.cn) ; Zhou, Zikai(zhouzikai@simm.ac.cn) |
| 英文摘要 | Accumulating evidence suggests long-lasting impairments in brain development and cognition caused by neonatal exposure to general anesthetics. To date, very little is known about potential abnormal psychiatric manifestations attributable to neonatal anesthesia. In this study, we used ketamine to induce anesthesia in neonatal mice. By applying mild stressors one day before behavioral tests, we found that adult mice exhibit significant anxiety-like behaviors that were indistinguishable at basal level. Recruitment of AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) type glutamate receptors into silent synapses is a prominent cellular process during neonatal neurodevelopment. We found that exposure to ketamine significantly disrupted synapse unsilencing, and impaired the expression of unsilencing-mediated long-term potentiation (LTP). Pharmacologically enhancement of neural activities by AMPAkine drug CX546 [1-(1,4-benzodioxan-6-ylcarbonyl) piperidine] effectively rescued disrupted developmental synapse unsilencing and LTP at neonatal age, and prevented stressor-evoked anxiety-like behaviors in adult mice. Together, our results indicate that neonatal exposure to ketamine may predispose individuals for psychiatric conditions via disrupting synapse unsilencing, and potentiation of neural activities during the anesthesia-recovery period may be an effective approach to manage adverse effects on brain development. This article is part of the special issue on 'Stress, Addiction and Plasticity'. |
| WOS关键词 | AWAKE-REGIONAL ANESTHESIA ; LONG-TERM POTENTIATION ; SILENT SYNAPSES ; GENERAL-ANESTHESIA ; INFANCY GAS ; SEVOFLURANE ; EXPRESSION ; PLASTICITY ; PERIOD ; MULTICENTER |
| 资助项目 | National Natural Science Foundation of China[81971022] ; National Natural Science Foundation of China[31571040] ; Program of Shanghai Academic Research Leader[19XD1423300] ; Shanghai Municipal Commission of Education-Gaofeng Clinical Medicine[20191835] |
| WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000593895300007 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/296209]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Zhang, Xiaoyun; Zhou, Zikai |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 2.Southeast Univ, Inst Life Sci, Key Lab Dev Genes & Human Dis, Minist Educ, Nanjing, Peoples R China 3.Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Sch Med, Shanghai, Peoples R China 4.Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiaoyun,Kong, Yue,He, Guiqin,et al. Neonatal exposure to ketamine disrupts developmental synapse unsilencing and predisposes adult mice for stressor-evoked anxiety[J]. NEUROPHARMACOLOGY,2020,180:12. |
| APA | Zhang, Xiaoyun,Kong, Yue,He, Guiqin,&Zhou, Zikai.(2020).Neonatal exposure to ketamine disrupts developmental synapse unsilencing and predisposes adult mice for stressor-evoked anxiety.NEUROPHARMACOLOGY,180,12. |
| MLA | Zhang, Xiaoyun,et al."Neonatal exposure to ketamine disrupts developmental synapse unsilencing and predisposes adult mice for stressor-evoked anxiety".NEUROPHARMACOLOGY 180(2020):12. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。