Harnessing Genomic Stress for Antitumor Immunity
文献类型：期刊论文
| 作者 | Pu, Congying1,2; Tao, Siyao1,2; Xu, Jun1,2; Huang, Min1,2
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| 刊名 | ANTIOXIDANTS & REDOX SIGNALING
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| 出版日期 | 2020-12-04 |
| 页码 | 23 |
| ISSN号 | 1523-0864 |
| 关键词 | genomic stress cancer genomic instability antitumor immunity |
| DOI | 10.1089/ars.2020.8221 |
| 通讯作者 | Huang, Min(mhuang@simm.ac.cn) |
| 英文摘要 | Significance: Genomic instability, a hallmark of cancer, renders cancer cells susceptible to genomic stress from both endogenous and exogenous origins, resulting in the increased tendency to accrue DNA damage, chromosomal instability, or aberrant DNA localization. Apart from the cell autonomous tumor-promoting effects, genomic stress in cancer cells could have a profound impact on the tumor microenvironment. Recent Advances: Recently, it is increasingly appreciated that harnessing genomic stress could provide a promising strategy to revive antitumor immunity, and thereby offer new therapeutic opportunities in cancer treatment. Critical Issues: Genomic stress is closely intertwined with antitumor immunity via mechanisms involving the direct crosstalk with DNA damage response components, upregulation of immune-stimulatory/inhibitory ligands, release of damage-associated molecular patterns, increase of neoantigen repertoire, and activation of DNA sensing pathways. A better understanding of these mechanisms will provide molecular basis for exploiting the genomic stress to boost antitumor immunity. Future Directions: Future research should pay attention to the heterogeneity between individual cancers in the genomic instability and the associated immune response, and how to balance the toxicity and benefit by specifying the types, potency, and treatment sequence of genomic stress inducer in therapeutic practice. |
| WOS关键词 | NF-KAPPA-B ; DNA-DAMAGE ; CHROMOSOMAL INSTABILITY ; COLORECTAL-CANCER ; TUMOR-CELLS ; CALRETICULIN EXPOSURE ; AIM2 INFLAMMASOME ; REPAIR DEFICIENCY ; CTLA-4 BLOCKADE ; DENDRITIC CELLS |
| 资助项目 | National Natural Science Foundation of China[81903640] ; National Natural Science Foundation of China[81821005] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020102] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| 出版者 | MARY ANN LIEBERT, INC |
| WOS记录号 | WOS:000595895400001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/296214]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Huang, Min |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pu, Congying,Tao, Siyao,Xu, Jun,et al. Harnessing Genomic Stress for Antitumor Immunity[J]. ANTIOXIDANTS & REDOX SIGNALING,2020:23. |
| APA | Pu, Congying,Tao, Siyao,Xu, Jun,&Huang, Min.(2020).Harnessing Genomic Stress for Antitumor Immunity.ANTIOXIDANTS & REDOX SIGNALING,23. |
| MLA | Pu, Congying,et al."Harnessing Genomic Stress for Antitumor Immunity".ANTIOXIDANTS & REDOX SIGNALING (2020):23. |
入库方式： OAI收割
来源：上海药物研究所
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