Resistance to Some But Not Other Dimeric Lindenane Sesquiterpenoid Esters Is Mediated by Mutations in a Plasmodium falciparum Esterase
文献类型：期刊论文
| 作者 | Butler, Joshua H.2,3; Baptista, Rodrigo P.3,4; Valenciano, Ana L.2,3; Zhou, Bin5,6; Kissinger, Jessica C.3,4,7; Tumwebaze, Patrick K.8; Rosenthal, Philip J.9; Cooper, Roland A.1; Yue, Jian-Min5,6 ; Cassera, Maria B.2,3
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| 刊名 | ACS INFECTIOUS DISEASES
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| 出版日期 | 2020-11-13 |
| 卷号 | 6期号:11页码:2994-3003 |
| ISSN号 | 2373-8227 |
| 关键词 | Plasmodium PfPARE structure-resistance relationship study Malaria Box Pathogen Box lindenane sesquiterpenoid dimers |
| DOI | 10.1021/acsinfecdis.0c00487 |
| 通讯作者 | Cassera, Maria B.(maria.cassera@uga.edu) |
| 英文摘要 | Unique lindenane sesquiterpenoid dimers from Chloranthecae spp. were recently identified with promising in vitro antiplasmodial activity and potentially novel mechanisms of action. To gain mechanistic insights to this new class of natural products, in vitro selection of Plasmodium falciparum resistance to the most active antiplasmodial compound, chlorajaponilide C, was explored. In all selected resistant clones, the half-maximal effective concentration (EC50) of chlorajaponilide C increased >250-fold, and whole genome sequencing revealed mutations in the recently discovered P. falciparum prodrug activation and resistance esterase (PfPARE). Chlorajaponilide C was highly potent (mean EC50 = 1.6 nM, n = 34) against fresh Ugandan P. falciparum isolates. The analysis of the structure-resistance relationships revealed that in vitro potency of a subset of lindenane sesquiterpenoid dimers was not mediated by PIPARE mutations. Thus, chlorajaponilide C, but not some related compounds, required parasite esterase activity for in vitro potency, and those compounds serve as the foundation for development of potent and selective antimalarials. |
| WOS关键词 | TRANSFER-RNA SYNTHETASE ; GENOME ; INHIBITION |
| 资助项目 | National Institutes of Health[AT008088] ; National Institutes of Health[T32-AI060546] ; National Institutes of Health[AI139179] ; MMV[RD/15/0001] ; National Natural Science Foundation of the P. R. China[21772212] |
| WOS研究方向 | Pharmacology & Pharmacy ; Infectious Diseases |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000592747600019 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/296248]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Cassera, Maria B. |
| 作者单位 | 1.Univ Calif, Dept Nat Sci & Math Dominican, San Rafael, CA 94901 USA 2.Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA 3.Univ Georgia, Ctr Trop & Emerging Global Dis CTEGD, Athens, GA 30602 USA 4.Univ Georgia, Inst Bioinformat, Athens, GA 30602 USA 5.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100864, Peoples R China 7.Univ Georgia, Dept Genet, Athens, GA 30602 USA 8.Infect Dis Res Collaborat, Kampala, Uganda 9.Univ Calif San Francisco, Dept Med, San Francisco, CA 94110 USA |
| 推荐引用方式 GB/T 7714 | Butler, Joshua H.,Baptista, Rodrigo P.,Valenciano, Ana L.,et al. Resistance to Some But Not Other Dimeric Lindenane Sesquiterpenoid Esters Is Mediated by Mutations in a Plasmodium falciparum Esterase[J]. ACS INFECTIOUS DISEASES,2020,6(11):2994-3003. |
| APA | Butler, Joshua H..,Baptista, Rodrigo P..,Valenciano, Ana L..,Zhou, Bin.,Kissinger, Jessica C..,...&Cassera, Maria B..(2020).Resistance to Some But Not Other Dimeric Lindenane Sesquiterpenoid Esters Is Mediated by Mutations in a Plasmodium falciparum Esterase.ACS INFECTIOUS DISEASES,6(11),2994-3003. |
| MLA | Butler, Joshua H.,et al."Resistance to Some But Not Other Dimeric Lindenane Sesquiterpenoid Esters Is Mediated by Mutations in a Plasmodium falciparum Esterase".ACS INFECTIOUS DISEASES 6.11(2020):2994-3003. |
入库方式： OAI收割
来源：上海药物研究所
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