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A novel salviadione derivative, compound 15a, attenuates diabetes-induced renal injury by inhibiting NF-kappa B-mediated inflammatory responses

文献类型：期刊论文

作者Li, Li2,3; Ding, Chunyong4; Zou, Chunpeng5; Xiong, Zhi1,6; Zhu, Weiwei2; Qian, Jianchang2; Xu, Mingjiang2; Zhang, Ao1,4; Liang, Guang2
刊名TOXICOLOGY AND APPLIED PHARMACOLOGY
出版日期2020-12-15
卷号409页码:11
关键词Salviadione derivative 15a Diabetic nephropathy Inflammation Macrophage infiltration Fibrosis Nuclear factor-kappa B Cytokines
ISSN号0041-008X
DOI10.1016/j.taap.2020.115322
通讯作者Zhang, Ao(ao6919zhang@sjtu.edu.cn) ; Liang, Guang(wzmcliangguang@163.com)
英文摘要Diabetic nephropathy is the leading cause of renal failure worldwide. Elevated inflammatory signaling has been shown to lead to deterioration of renal function in human and experimental diabetes. We recently developed a salviadione derivative (compound 15a) that prevented microbial lipopolysaccharide-induced inflammatory responses, which are largely driven by nuclear factor-kappa B (NF-kappa B). In the present study, we have tested the hypothesis that 15a will protect kidneys from diabetes-induced dysfunction by suppressing NF-kappa B activation and inflammatory signaling. Treatment of diabetic mice with 15a inhibited diabetes-induced renal fibrosis, NF-kappa B activation, and upregulation of proinflammatory cytokines. Histologically, kidney specimens from diabetic mice treated with 15a were indistinguishable from non-diabetic controls. We confirmed our findings in cultured renal tubular epithelial cells exposed to high levels of glucose. In these cultured cells, 15a pretreatment prevented high glucose-induced NF-kappa B activation and expression of inflammatory cytokines. These protective effects were also reflected in reduced levels of proteins involved in matrix expansion. Overall, our studies show that a salviadione derivative, 15a, is effective in suppressing diabetes-induced NF-kappa B activation and inflammatory signaling.
WOS关键词OXIDATIVE STRESS ; IN-VIVO ; NEPHROPATHY ; ACTIVATION ; MILTIORRHIZA ; MACROPHAGES ; PROGRESSION ; EXPRESSION ; MOLECULE-1 ; APOPTOSIS
资助项目National Key Research Project[2017YFA0506000] ; National Natural Science Foundation of China[21961142009] ; National Natural Science Foundation of China[81803600] ; National Natural Science Foundation of China[81970323] ; Zhejiang Provincial Key Scientific Project[2018C03068] ; Wenzhou Key Scientific Project[2018ZY009]
WOS研究方向Pharmacology & Pharmacy ; Toxicology
语种英语
WOS记录号WOS:000599506300006
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/296263]  
专题中国科学院上海药物研究所
通讯作者Zhang, Ao; Liang, Guang
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Wenzhou Med Univ, Chem Biol Res Ctr, Sch Pharmaceut Sci, Wenzhou, Zhejiang, Peoples R China
3.Zhejiang Univ, Affiliated Hosp 4, Sch Med, Dept Anesthesiol, Yiwu, Zhejiang, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai, Peoples R China
5.Wenzhou Med Univ, Affiliated Hosp 2, Dept Ultrasonog, Wenzhou, Zhejiang, Peoples R China
6.Nanchang Univ, Sch Pharm, Nanchang 330031, Jiangxi, Peoples R China
推荐引用方式
GB/T 7714		 Li, Li,Ding, Chunyong,Zou, Chunpeng,et al. A novel salviadione derivative, compound 15a, attenuates diabetes-induced renal injury by inhibiting NF-kappa B-mediated inflammatory responses[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY,2020,409:11.
APA Li, Li.,Ding, Chunyong.,Zou, Chunpeng.,Xiong, Zhi.,Zhu, Weiwei.,...&Liang, Guang.(2020).A novel salviadione derivative, compound 15a, attenuates diabetes-induced renal injury by inhibiting NF-kappa B-mediated inflammatory responses.TOXICOLOGY AND APPLIED PHARMACOLOGY,409,11.
MLA Li, Li,et al."A novel salviadione derivative, compound 15a, attenuates diabetes-induced renal injury by inhibiting NF-kappa B-mediated inflammatory responses".TOXICOLOGY AND APPLIED PHARMACOLOGY 409(2020):11.

入库方式： OAI收割

来源：上海药物研究所

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