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Phytochemicals from the Leaves of Cyclocarya paliurus and their 11 beta-HSD1 Enzyme Inhibitory Effects

文献类型：期刊论文

作者Yan, Huan2,3; Li, Xiang2,3,4; Ni, Wei2,3; Zhao, Qing4; Leng, Ying1; Liu, Hai-Yang2,3
刊名CHEMISTRY & BIODIVERSITY
出版日期2020-12-28
页码7
ISSN号1612-1872
关键词Cyclocarya paliurus dammarane-type triterpenoid saponins 11β -HSD1 enzyme inhibitory activity
DOI10.1002/cbdv.202000772
通讯作者Liu, Hai-Yang(haiyangliu@mail.kib.ac.cn)
英文摘要Two new dammarane-type triterpenoid saponins, 3 beta-(alpha-l-arabinopyranosyloxy)-24,25-dihydroxydammar-20-en-12 alpha-yl 6-deoxy-beta-d-glucopyranoside (1) and (24R)-3 beta-[(4-O-acetyl-alpha-l-arabinopyranosyl)oxy]-25-hydroxy-20,24-epoxydammaran-12 beta-yl 6-deoxy-beta-d-glucopyranoside (2), and fourteen known triterpenoids were isolated from the 70 % MeOH extract of the leaves of Cyclocarya paliurus. Their structures were established based on analyses of spectroscopic data. All compounds were tested for their inhibitory activities against the 11 beta-HSD1 enzyme. Hederagenin (13) exhibited moderate inhibitory effect for mouse 11 beta-HSD1 with an IC50 value of 0.16 +/- 0.04 mu M.
WOS关键词ANTIOXIDANT ACTIVITIES ; CHEMICAL-CONSTITUENTS ; DEHYDROGENASE TYPE-1 ; TRITERPENOIDS ; POLYSACCHARIDE ; SAPONINS
资助项目National Natural Science Foundation of China[U1802287] ; National Natural Science Foundation of China[32000280] ; Ten Thousand Talents Plan of Yunnan Province for Industrial Technology Leading Talents ; Major Biomedical Project of Yunnan Province[2019ZF010] ; State Key Laboratory of Phytochemistry and Plant Resources in West China[P2019-ZZ02]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000602674800001
源URL[http://119.78.100.183/handle/2S10ELR8/296305]  
专题新药研究国家重点实验室
通讯作者Liu, Hai-Yang
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
3.Chinese Acad Sci, Kunming Inst Bot, Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China
4.Yunnan Univ Chinese Med, Kunming 650500, Yunnan, Peoples R China
推荐引用方式
GB/T 7714		 Yan, Huan,Li, Xiang,Ni, Wei,et al. Phytochemicals from the Leaves of Cyclocarya paliurus and their 11 beta-HSD1 Enzyme Inhibitory Effects[J]. CHEMISTRY & BIODIVERSITY,2020:7.
APA Yan, Huan,Li, Xiang,Ni, Wei,Zhao, Qing,Leng, Ying,&Liu, Hai-Yang.(2020).Phytochemicals from the Leaves of Cyclocarya paliurus and their 11 beta-HSD1 Enzyme Inhibitory Effects.CHEMISTRY & BIODIVERSITY,7.
MLA Yan, Huan,et al."Phytochemicals from the Leaves of Cyclocarya paliurus and their 11 beta-HSD1 Enzyme Inhibitory Effects".CHEMISTRY & BIODIVERSITY (2020):7.

入库方式： OAI收割

来源：上海药物研究所

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