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1-Phenyl-N-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors

文献类型：期刊论文

作者Hu, Min-Qi2; Li, Heng1,3; Lin, Ying2; Zhang, Ying2; Tang, Jie2,4; Zuo, Jian-Ping3; Yu, Li-Fang2; Tong, Xian-Kun1,3; Tang, Wei1,3; Yang, Fan2
刊名RSC ADVANCES
出版日期2020-12-07
卷号10期号:71页码:43299-43311
DOI10.1039/d0ra08442e
通讯作者Tong, Xian-Kun(xktong@simm.ac.cn) ; Tang, Wei(tangwei@simm.ac.cn) ; Yang, Fan(fyang@chem.ecnu.edu.cn)
英文摘要Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to human health, and currently there are no effective or specific therapies available to treat it. Herein a series of 1-phenyl-N-(benzothiazol-2-yl)methanimine derivatives with inhibitory activity against MERS-CoV are described. The compound 4f with a 50% inhibition concentration value of 0.09 mu M is a promising inhibitor that warrants further evaluation, towards the development of potential anti-MERS-CoV drugs.
WOS关键词RECEPTOR-BINDING DOMAIN ; SARS-CORONAVIRUS ; SAUDI-ARABIA ; S PROTEIN ; MERS ; TRANSMISSION ; ANTIBODY ; DISEASE
资助项目National Key Research and Development Program of China[2018YFC1200604]
WOS研究方向Chemistry
语种英语
出版者ROYAL SOC CHEMISTRY
WOS记录号WOS:000599464100007
源URL[http://119.78.100.183/handle/2S10ELR8/296316]  
专题中国科学院上海药物研究所
通讯作者Tong, Xian-Kun; Tang, Wei; Yang, Fan
作者单位1.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
2.East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Sch Chem & Mol Engn, Shanghai 200062, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
4.Shanghai Greenchem & Biotech Co Ltd, Shanghai 200062, Peoples R China
推荐引用方式
GB/T 7714		 Hu, Min-Qi,Li, Heng,Lin, Ying,et al. 1-Phenyl-N-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors[J]. RSC ADVANCES,2020,10(71):43299-43311.
APA Hu, Min-Qi.,Li, Heng.,Lin, Ying.,Zhang, Ying.,Tang, Jie.,...&Yang, Fan.(2020).1-Phenyl-N-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors.RSC ADVANCES,10(71),43299-43311.
MLA Hu, Min-Qi,et al."1-Phenyl-N-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors".RSC ADVANCES 10.71(2020):43299-43311.

入库方式： OAI收割

来源：上海药物研究所

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