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Rhodium(III)-Catalyzed C-H Alkenylation/Directing Group Migration for the Regio- and Stereoselective Synthesis of Tetrasubstituted Alkenes

文献类型：期刊论文

作者Wu, Xiaowei2,3; Lu, Yangbin4,5; Qiao, Jin4; Dai, Wenhao1; Jia, Xiuwen2; Ni, Hangcheng4; Zhang, Xiaoning4; Liu, Hong1; Zhao, Fei2,4
刊名ORGANIC LETTERS
出版日期2020-12-04
卷号22期号:23页码:9163-9168
ISSN号1523-7060
DOI10.1021/acs.orglett.0c03077
通讯作者Zhang, Xiaoning(xiaozhangningsunny@163.com) ; Liu, Hong(hliu@simm.ac.cn) ; Zhao, Fei(zhaofei@cdu.edu.cn)
英文摘要An efficient Rh(III)-catalyzed C-H alkenylation/directing group migration cascade between indoles and alkynes for the assembly of tetrasubstituted alkenes is reported. The carbamoyl directing group migrates to the carbon of the alkene moiety of the products through rare Rh-catalyzed C-N bond cleavage after the C-H alkenylation step and thus acts as an internal amidation reagent. This protocol shows broad substrate scope, excellent regio/stereoselectivity, and good to excellent yields.
WOS关键词BOND FORMATION ; N-PHENOXYACETAMIDES ; EFFICIENT ACCESS ; INTERNAL ALKYNES ; DIRECT ADDITION ; DIRECTING GROUP ; INDOLES ; OLEFINATION ; HYDROARYLATION ; ARENES
资助项目Natural Science Foundation of Zhejiang Province[LY21B020003] ; National Natural Science Foundation of China[21602022] ; National Natural Science Foundation of China[21672232] ; National Natural Science Foundation of China[21977106] ; National Natural Science Foundation of China[21632008] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12020375] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12050411] ; Chengdu Talents Program ; 1000 Talents Program of Sichuan Province ; Science and Technology Program of Sichuan Province[2018JY0345] ; Jinhua Branch of Sichuan Industrial Institute of Antibiotics[1003] ; Chengdu University[2081915037] ; Chenghua District Talents Program
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000598141000004
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/296385]  
专题新药研究国家重点实验室
通讯作者Zhang, Xiaoning; Liu, Hong; Zhao, Fei
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Chengdu Univ, Sichuan Ind Inst Antibiot, Antibiot Res & Reevaluat Key Lab Sichuan Prov, Chengdu 610052, Peoples R China
3.Baylor Coll Med, Dept Pharmacol & Chem Biol, Houston, TX 77030 USA
4.Chengdu Univ, Sichuan Ind Inst Antibiot, Jinhua Branch, Jinhua 321007, Zhejiang, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Xiaowei,Lu, Yangbin,Qiao, Jin,et al. Rhodium(III)-Catalyzed C-H Alkenylation/Directing Group Migration for the Regio- and Stereoselective Synthesis of Tetrasubstituted Alkenes[J]. ORGANIC LETTERS,2020,22(23):9163-9168.
APA Wu, Xiaowei.,Lu, Yangbin.,Qiao, Jin.,Dai, Wenhao.,Jia, Xiuwen.,...&Zhao, Fei.(2020).Rhodium(III)-Catalyzed C-H Alkenylation/Directing Group Migration for the Regio- and Stereoselective Synthesis of Tetrasubstituted Alkenes.ORGANIC LETTERS,22(23),9163-9168.
MLA Wu, Xiaowei,et al."Rhodium(III)-Catalyzed C-H Alkenylation/Directing Group Migration for the Regio- and Stereoselective Synthesis of Tetrasubstituted Alkenes".ORGANIC LETTERS 22.23(2020):9163-9168.

入库方式： OAI收割

来源：上海药物研究所

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