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Deformable liposomal codelivery of vorinostat and simvastatin promotes antitumor responses through remodeling tumor microenvironment

文献类型：期刊论文

作者Tu, Bin3,4; He, Yang3,4; Chen, Binfan3,4; Wang, Yonghui3,4; Gao, Yanrong3,4; Shi, Mingjie3; Liu, Tuanbing3; Asrorov, Akmal M.1,3; Huang, Yongzhuo2,3,4,5
刊名BIOMATERIALS SCIENCE
出版日期2020-12-21
卷号8期号:24页码:7166-7176
ISSN号2047-4830
DOI10.1039/d0bm01516d
通讯作者Huang, Yongzhuo(yzhuang@simm.ac.cn)
英文摘要The tumor microenvironment (TME) and its major component tumor-associated macrophages (TAM) play a pivotal role in the development of non-small cell lung cancer (NSCLC). An epigenetic drug-based combinatory therapeutic strategy was proposed and a deformable liposome system (D-Lipo) was developed for vorinostat and simvastatin codelivery for remodeling the TME. The application of deformable liposomes in systemic cancer drug delivery has been underexplored and its potential in cancer therapy is largely unknown. This work revealed that D-Lipo exhibited an enhanced intratumor infiltration ability. The proposed therapeutic strategy was characterized by a chemo-free regimen and TME remodeling function. D-Lipo efficiently inhibited the growth of the xenografted lung tumor. The anti-tumor mechanisms involved the repolarization of TAM from the M2 to M1 phenotype, anti-angiogenesis, and the consequent TME remodeling. As a result, the amounts of the anti-tumor M1 macrophages and the cytotoxic CD8(+) T cells increased, while the amounts of the pro-tumor M2 macrophages and regulatory T cells (Tregs) reduced. It provides a promising avenue for epigenetic drug-based combination therapy for treating solid tumors.
WOS关键词CELL LUNG-CANCER ; LIPID-METABOLISM ; DELIVERY ; PATHWAY ; MACROPHAGES ; INHIBITION ; EXPRESSION ; RESISTANCE ; BRAIN ; VEGF
资助项目NFSC[81925035] ; NFSC[81673382] ; NFSC[81521005] ; Strategic Priority Research Program of CAS[XDA12050307] ; National Special Project for Significant New Drugs Development[2018ZX09711002-010-002] ; Shanghai SciTech Innovation Initiative[19431903100] ; Shanghai Belt and Road Initiative Young Foreign Scientists Program[18430740800] ; Shanghai Collaborative Innovation Group of Early Diagnosis and Precise Treatment of Hemangiomas and Vascular Malformations[SSMU-ZDCX20180701] ; CAS PIFI fellowship
WOS研究方向Materials Science
语种英语
出版者ROYAL SOC CHEMISTRY
WOS记录号WOS:000600664500027
源URL[http://119.78.100.183/handle/2S10ELR8/296407]  
专题新药研究国家重点实验室
通讯作者Huang, Yongzhuo
作者单位1.Acad Sci Uzbek, Inst Bioorgan Chem, 83 M Ulughbek St, Tashkent 100125, Uzbekistan
2.Chinese Acad Sci, Inst Drug Res & Dev, Zhongshan Branch, Zhongshan 528437, Peoples R China
3.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.NAIPA Key Lab Qual Res & Evaluat Pharmaceut Excip, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Tu, Bin,He, Yang,Chen, Binfan,et al. Deformable liposomal codelivery of vorinostat and simvastatin promotes antitumor responses through remodeling tumor microenvironment[J]. BIOMATERIALS SCIENCE,2020,8(24):7166-7176.
APA Tu, Bin.,He, Yang.,Chen, Binfan.,Wang, Yonghui.,Gao, Yanrong.,...&Huang, Yongzhuo.(2020).Deformable liposomal codelivery of vorinostat and simvastatin promotes antitumor responses through remodeling tumor microenvironment.BIOMATERIALS SCIENCE,8(24),7166-7176.
MLA Tu, Bin,et al."Deformable liposomal codelivery of vorinostat and simvastatin promotes antitumor responses through remodeling tumor microenvironment".BIOMATERIALS SCIENCE 8.24(2020):7166-7176.

入库方式： OAI收割

来源：上海药物研究所

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