Fluorescent probes for the imaging of lipid droplets in live cells
文献类型：期刊论文
| 作者 | Tian, He, Jr.2,3; Sedgwick, Adam C.5; Han, Hai-Hao2,3; Sen, Sajal5; Chen, Guo-Rong2,3; Zang, Yi4 ; Sessler, Jonathan L.5; James, Tony D.1; Li, Jia4; He, Xiao-Peng2,3
|
| 刊名 | COORDINATION CHEMISTRY REVIEWS
 |
| 出版日期 | 2021-01-15 |
| 卷号 | 427页码:14 |
| 关键词 | Lipid droplets (LDs) Fluorescent probes Intramolecular charge transfer (ICT) Aggregation-induced emission (AIE) Cellular imaging |
| ISSN号 | 0010-8545 |
| DOI | 10.1016/j.ccr.2020.213577 |
| 通讯作者 | Sessler, Jonathan L.(sessler@cm.utexas.edu) ; James, Tony D.(t.d.james@bath.ac.uk) ; Li, Jia(jli@simm.ac.cn) ; He, Xiao-Peng(xphe@ecust.edu.cn) |
| 英文摘要 | Lipid droplets (LDs) are cellular organelles that are essential for maintaining lipid and energy homeostasis. Once regarded as merely inert fat particles, they are now recognized as highly dynamic, mobile organelles required for preventing lipotoxicity and for interacting and cooperating with various organelles. Despite the progress made in understanding the role of LDs, a number of fundamental questions remain unanswered. Effective imaging agents for observing the morphology and dynamic physiological processes of LDs in cells could help address this knowledge gap. Such probes are expected to aid in our understanding of LDs and facilitate the development of new and effective therapeutics. In this review, we have provided a brief introduction to the formation and physiological functions of LDs in an attempt to highlight the importance of these underappreciated organelles. Recent examples of LD-based fluorescent probes are discussed, including the fluorescence phenomenon used in their design. To date, both intramolecular charge transfer (ICT) and aggregation-induced emission (AIE) fluorescence mechanisms have been exploited to create LD probes. However, alternative strategies can be envisioned. We hope the readers will be enlightened as to the importance of these key organelles, will be poised to exploit existing probes to explore various biological applications, and be inspired to create new LD fluorescent sensors that will further our understanding of LDs and their associated physiology. (C) 2020 Published by Elsevier B.V. |
| WOS关键词 | AGGREGATION-INDUCED EMISSION ; REAL-TIME ; ENERGY ; AIEGEN ; STATES ; RAB7-RILP-P150(GLUED) ; ROTATIONS ; PROTEINS ; TRACKING ; SURVIVAL |
| 资助项目 | NSFC[21788102] ; NSFC[91853201] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; National Key Sci-Tech Special Projects of Infection Diseases of China[2018ZX10732202] ; International Cooperation Program of Shanghai Science and Technology Committee[17520750100] ; Robert A. Welch Foundation[F-0018] ; Royal Society |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000588407500037 |
| 出版者 | ELSEVIER SCIENCE SA |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/296441]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Sessler, Jonathan L.; James, Tony D.; Li, Jia; He, Xiao-Peng |
| 作者单位 | 1.Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England 2.East China Univ Sci & Technol, Key Lab Adv Mat, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn,Frontiers Ctr Materiobiol & D, 130 Meilong Rd, Shanghai 200237, Peoples R China 3.East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn,Frontiers Ctr Materiobiol & D, 130 Meilong Rd, Shanghai 200237, Peoples R China 4.Chinese Acad Sci, Natl Ctr Drug Screening, Shanghai Inst Mat Med, State Key Lab Drug Res, 189 Guo Shoujing Rd, Shanghai 201203, Peoples R China 5.Univ Texas Austin, Dept Chem, 105 E 24th St A5300, Austin, TX 78712 USA |
| 推荐引用方式 GB/T 7714 | Tian, He, Jr.,Sedgwick, Adam C.,Han, Hai-Hao,et al. Fluorescent probes for the imaging of lipid droplets in live cells[J]. COORDINATION CHEMISTRY REVIEWS,2021,427:14. |
| APA | Tian, He, Jr..,Sedgwick, Adam C..,Han, Hai-Hao.,Sen, Sajal.,Chen, Guo-Rong.,...&He, Xiao-Peng.(2021).Fluorescent probes for the imaging of lipid droplets in live cells.COORDINATION CHEMISTRY REVIEWS,427,14. |
| MLA | Tian, He, Jr.,et al."Fluorescent probes for the imaging of lipid droplets in live cells".COORDINATION CHEMISTRY REVIEWS 427(2021):14. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。