Uncommon terpenoids with anti-inflammatory activity from the Hainan soft coral Sinularia tumulosa
文献类型：期刊论文
| 作者 | Cai, You-Sheng1; Cui, Wan-Xiang2; Tang, Wei2 ; Guo, Yue-Wei2
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| 刊名 | BIOORGANIC CHEMISTRY
 |
| 出版日期 | 2020-11-01 |
| 卷号 | 104页码:8 |
| 关键词 | Peroxide Sinularia tumulosa Terpenoids Anti-inflammatory activity |
| ISSN号 | 0045-2068 |
| DOI | 10.1016/j.bioorg.2020.104167 |
| 通讯作者 | Guo, Yue-Wei(ywguo@simm.ac.cn) |
| 英文摘要 | One novel sesquiterpenoid containing an unprecedented eight-membered cyclic peroxide motif, sinulatumolin A (1), along with four new related terpenoids, namely sinulatumolins B-E (2-4 and 6), were isolated from South China Sea soft coral Sinularia tumulosa. The structures of all the isolates were elucidated by detailed spectroscopic analysis, chemical transformations, and single X-ray diffraction analysis. Compound 1 represents the first example of sesquiterpene bearing an eight-membered cyclic peroxide ring from soft coral. All the new compounds isolated were evaluated for their anti-inflammatory activity. Compounds 1, 3, 4 and 6 displayed significant TNF-alpha inhibitory activity being comparable with that of the positive control dexamethasone (IC50 = 8.7 mu M), with IC50 values of 7.5, 2.6, 5.5, and 3.6 mu M, respectively. |
| WOS关键词 | TIXIER-DURIVAULT ; METABOLITES ; SESQUITERPENOIDS |
| 资助项目 | Natural Science Foundation of China[81991521] ; Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[81973201] ; Natural Science Foundation of China[81860613] ; Drug Innovation Major Project[2018ZX09711-001-001-009] ; SKLDR/SIMM Project[SIMM1903ZZ-04] ; Fundamental Research Funds for the Central Universities[2042019kf0228] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000592395300012 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/296460]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Guo, Yue-Wei |
| 作者单位 | 1.Wuhan Univ, Inst TCM & Nat Prod, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cai, You-Sheng,Cui, Wan-Xiang,Tang, Wei,et al. Uncommon terpenoids with anti-inflammatory activity from the Hainan soft coral Sinularia tumulosa[J]. BIOORGANIC CHEMISTRY,2020,104:8. |
| APA | Cai, You-Sheng,Cui, Wan-Xiang,Tang, Wei,&Guo, Yue-Wei.(2020).Uncommon terpenoids with anti-inflammatory activity from the Hainan soft coral Sinularia tumulosa.BIOORGANIC CHEMISTRY,104,8. |
| MLA | Cai, You-Sheng,et al."Uncommon terpenoids with anti-inflammatory activity from the Hainan soft coral Sinularia tumulosa".BIOORGANIC CHEMISTRY 104(2020):8. |
入库方式： OAI收割
来源：上海药物研究所
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