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Heme supplementation ameliorates lupus nephritis through rectifying the disorder of splenocytes and alleviating renal inflammation and oxidative damage

文献类型：期刊论文

作者Wu, Bing1,2; Wu, Yanwei1; Fan, Chen1; Feng, Chunlan1; Wang, Haoyu1,2; Bai, Fang1,2; Zuo, Jianping2,3; Tang, Wei1,2
刊名INTERNATIONAL IMMUNOPHARMACOLOGY
出版日期2021-05-01
卷号94页码:11
ISSN号1567-5769
关键词SLE Lupus nephritis Heme Inflammation Oxidative damage
DOI10.1016/j.intimp.2021.107482
通讯作者Zuo, Jianping(jpzuo@simm.ac.cn) ; Tang, Wei(tangwei@simm.ac.cn)
英文摘要Heme is an important iron-containing porphyrin molecule expressed ubiquitously in organisms. Recently, this endogenous molecule has been widely reported to be involved in the pathogenesis of numerous diseases such as sepsis, atherosclerosis and inflammatory bowel disease. However, the role of heme during systemic lupus erythematosus (SLE) pathogenesis has not been previously evaluated. Herein, we have measured the levels of heme in lupus-prone mice and explored the influence of heme on the pathogenesis of lupus. We revealed that heme levels in serum, kidney and spleen lymphocytes are all negatively associated with the levels of proteinuria in lupus-prone mice. Heme supplementation at 15 mg/kg could significantly ameliorate the syndromes of lupus in MRL/lpr mice, extending lifespan, reducing the level of proteinuria and alleviating splenomegaly and lymphadenopathy. Further study demonstrated that heme replenishment corrected the abnormal compartment of T cell subsets, plasma cells and macrophages in the spleen and alleviates inflammation and oxidative damage in kidney of MRL/lpr mice. Our study well defined heme as a relevant endogenous molecule in the etiology of SLE, as well as a potential therapeutic target for treating this autoimmune disease. Meanwhile, heme replenishment might be a new choice to therapeutically modulate immune homeostasis and prevent SLE.
WOS关键词ERYTHEMATOSUS ; OXYGENASE ; MACROPHAGES ; EXPRESSION ; INDUCTION ; MODEL ; CELL
资助项目National Natural Science Foundation of China[81673445] ; National Natural Science Foundation of China[81803543] ; Shanghai Committee of Science and Technology, China[18431901200] ; Shanghai Committee of Science and Technology, China[18431907100] ; national Science & Technology Major Project New Drug Creation and Manufacturing Program, China[2017ZX09101002-002-010]
WOS研究方向Immunology ; Pharmacology & Pharmacy
语种英语
出版者ELSEVIER
WOS记录号WOS:000644429000004
源URL[http://119.78.100.183/handle/2S10ELR8/296512]  
专题新药研究国家重点实验室
通讯作者Zuo, Jianping; Tang, Wei
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Antiinflammat, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, Sch Pharm, Beijing, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, State Key Lab Drug Res, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Wu, Bing,Wu, Yanwei,Fan, Chen,et al. Heme supplementation ameliorates lupus nephritis through rectifying the disorder of splenocytes and alleviating renal inflammation and oxidative damage[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2021,94:11.
APA Wu, Bing.,Wu, Yanwei.,Fan, Chen.,Feng, Chunlan.,Wang, Haoyu.,...&Tang, Wei.(2021).Heme supplementation ameliorates lupus nephritis through rectifying the disorder of splenocytes and alleviating renal inflammation and oxidative damage.INTERNATIONAL IMMUNOPHARMACOLOGY,94,11.
MLA Wu, Bing,et al."Heme supplementation ameliorates lupus nephritis through rectifying the disorder of splenocytes and alleviating renal inflammation and oxidative damage".INTERNATIONAL IMMUNOPHARMACOLOGY 94(2021):11.

入库方式： OAI收割

来源：上海药物研究所

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