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Regioselective Pd-catalyzed alpha-alkylation of furans using alkyl iodides

文献类型：期刊论文

作者Yuan, Jiaqi1,2; Zhang, Xiaofei1; Yang, Chunhao1,2
刊名RSC ADVANCES
出版日期2021-04-23
卷号11期号:23页码:13832-13838
DOI10.1039/d1ra01522b
通讯作者Zhang, Xiaofei(xiaofeizhang@simm.ac.cn) ; Yang, Chunhao(chyang@simm.ac.cn)
英文摘要Herein, direct alkylation of the C-H bond at the alpha-position of furans catalyzed by palladium catalyst is reported. This protocol targets alpha-alkylfurans, achieving moderate to good yields under very practical reaction conditions. With a broad scope of substrates and good functional group tolerance, this method will has promising utility in medicinal chemistry.
WOS关键词HYDROHETEROARYLATION ; HETEROARENES ; DISCOVERY ; SECONDARY ; PYRIDINE ; ALKENES ; DESIGN ; POTENT ; ACID
资助项目Science and Technology Commission of Shanghai Municipality[18431907100] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120185003] ; State Key Laboratory of Drug Research Program[SIMM1903ZZ-03]
WOS研究方向Chemistry
语种英语
出版者ROYAL SOC CHEMISTRY
WOS记录号WOS:000641127700016
源URL[http://119.78.100.183/handle/2S10ELR8/296543]  
专题新药研究国家重点实验室
通讯作者Zhang, Xiaofei; Yang, Chunhao
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, Sch Pharm, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Yuan, Jiaqi,Zhang, Xiaofei,Yang, Chunhao. Regioselective Pd-catalyzed alpha-alkylation of furans using alkyl iodides[J]. RSC ADVANCES,2021,11(23):13832-13838.
APA Yuan, Jiaqi,Zhang, Xiaofei,&Yang, Chunhao.(2021).Regioselective Pd-catalyzed alpha-alkylation of furans using alkyl iodides.RSC ADVANCES,11(23),13832-13838.
MLA Yuan, Jiaqi,et al."Regioselective Pd-catalyzed alpha-alkylation of furans using alkyl iodides".RSC ADVANCES 11.23(2021):13832-13838.

入库方式： OAI收割

来源：上海药物研究所

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