Trichloranoids A-D, antimalarial sesquiterpenoid trimers from Chloranthus spicatus
文献类型：期刊论文
| 作者 | Zhou, Jun-Su1,2; Liu, Qun-Fang1 ; Zimbres, Flavia M.3,4; Butler, Joshua H.3,4; Cassera, Maria B.3,4; Zhou, Bin1; Yue, Jian-Min1,2,5
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| 刊名 | ORGANIC CHEMISTRY FRONTIERS
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| 出版日期 | 2021-04-21 |
| 卷号 | 8期号:8页码:1795-1801 |
| ISSN号 | 2052-4129 |
| DOI | 10.1039/d1qo00089f |
| 通讯作者 | Zhou, Bin(zbbrush@126.com) ; Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | Four new lindenane sesquiterpenoid trimers, designated as trichloranoids A-D (1-4), along with a known analogue (5) were isolated from Chloranthus spicatus. Their structures were elucidated by a combination of diverse methods, including DP4+ probability and TDDFT-ECD calculations. Compounds 1 and 2 incorporated one unprecedented skeletal unit respectively in their western hemisphere, and each of them was likely formed biogenetically via a biradical rearrangement of the vinylcyclopropane. Compounds 1, 4, and 5 exhibited moderate antimalarial activities. |
| WOS关键词 | DIMERS ; ASSIGNMENT ; BLOCKERS ; POTENT ; PLANTS |
| 资助项目 | National Natural Science Foundation[21772212] ; CAMS Innovation Fund for Medical Sciences[2019-I2M-5-080] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000641898600007 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/296620]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhou, Bin; Yue, Jian-Min |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA 4.Univ Georgia, Ctr Trop & Emerging Global Dis CTEGD, Athens, GA 30602 USA 5.Chinese Acad Sci, Res Units Discovery New Drug Lead Mol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Jun-Su,Liu, Qun-Fang,Zimbres, Flavia M.,et al. Trichloranoids A-D, antimalarial sesquiterpenoid trimers from Chloranthus spicatus[J]. ORGANIC CHEMISTRY FRONTIERS,2021,8(8):1795-1801. |
| APA | Zhou, Jun-Su.,Liu, Qun-Fang.,Zimbres, Flavia M..,Butler, Joshua H..,Cassera, Maria B..,...&Yue, Jian-Min.(2021).Trichloranoids A-D, antimalarial sesquiterpenoid trimers from Chloranthus spicatus.ORGANIC CHEMISTRY FRONTIERS,8(8),1795-1801. |
| MLA | Zhou, Jun-Su,et al."Trichloranoids A-D, antimalarial sesquiterpenoid trimers from Chloranthus spicatus".ORGANIC CHEMISTRY FRONTIERS 8.8(2021):1795-1801. |
入库方式： OAI收割
来源：上海药物研究所
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