中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Trichloranoids A-D, antimalarial sesquiterpenoid trimers from Chloranthus spicatus

文献类型:期刊论文

作者Zhou, Jun-Su1,2; Liu, Qun-Fang1; Zimbres, Flavia M.3,4; Butler, Joshua H.3,4; Cassera, Maria B.3,4; Zhou, Bin1; Yue, Jian-Min1,2,5
刊名ORGANIC CHEMISTRY FRONTIERS
出版日期2021-04-21
卷号8期号:8页码:1795-1801
ISSN号2052-4129
DOI10.1039/d1qo00089f
通讯作者Zhou, Bin(zbbrush@126.com) ; Yue, Jian-Min(jmyue@simm.ac.cn)
英文摘要Four new lindenane sesquiterpenoid trimers, designated as trichloranoids A-D (1-4), along with a known analogue (5) were isolated from Chloranthus spicatus. Their structures were elucidated by a combination of diverse methods, including DP4+ probability and TDDFT-ECD calculations. Compounds 1 and 2 incorporated one unprecedented skeletal unit respectively in their western hemisphere, and each of them was likely formed biogenetically via a biradical rearrangement of the vinylcyclopropane. Compounds 1, 4, and 5 exhibited moderate antimalarial activities.
WOS关键词DIMERS ; ASSIGNMENT ; BLOCKERS ; POTENT ; PLANTS
资助项目National Natural Science Foundation[21772212] ; CAMS Innovation Fund for Medical Sciences[2019-I2M-5-080]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000641898600007
出版者ROYAL SOC CHEMISTRY
源URL[http://119.78.100.183/handle/2S10ELR8/296620]  
专题新药研究国家重点实验室
通讯作者Zhou, Bin; Yue, Jian-Min
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA
4.Univ Georgia, Ctr Trop & Emerging Global Dis CTEGD, Athens, GA 30602 USA
5.Chinese Acad Sci, Res Units Discovery New Drug Lead Mol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Jun-Su,Liu, Qun-Fang,Zimbres, Flavia M.,et al. Trichloranoids A-D, antimalarial sesquiterpenoid trimers from Chloranthus spicatus[J]. ORGANIC CHEMISTRY FRONTIERS,2021,8(8):1795-1801.
APA Zhou, Jun-Su.,Liu, Qun-Fang.,Zimbres, Flavia M..,Butler, Joshua H..,Cassera, Maria B..,...&Yue, Jian-Min.(2021).Trichloranoids A-D, antimalarial sesquiterpenoid trimers from Chloranthus spicatus.ORGANIC CHEMISTRY FRONTIERS,8(8),1795-1801.
MLA Zhou, Jun-Su,et al."Trichloranoids A-D, antimalarial sesquiterpenoid trimers from Chloranthus spicatus".ORGANIC CHEMISTRY FRONTIERS 8.8(2021):1795-1801.

入库方式: OAI收割

来源:上海药物研究所

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