In vitro studies of deferasirox derivatives as potential organelle-targeting traceable anti-cancer therapeutics
文献类型：期刊论文
| 作者 | Steinbrueck, Axel1; Sedgwick, Adam C.1; Han, Hai-Hao2,3; Zhao, Michael Y.1; Sen, Sajal1; Huang, Dan-Ying1; Zang, Yi; Li, Jia4 ; He, Xiao-Peng2,3; Sessler, Jonathan L.1
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| 刊名 | CHEMICAL COMMUNICATIONS
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| 出版日期 | 2021-05-04 |
| 页码 | 4 |
| ISSN号 | 1359-7345 |
| DOI | 10.1039/d0cc08156f |
| 通讯作者 | Li, Jia(jli@simm.ac.cn) ; He, Xiao-Peng(xphe@ecust.edu.cn) ; Sessler, Jonathan L.(sessler@cm.utexas.edu) |
| 英文摘要 | We report here strategic functionalization of the FDA approved chelator deferasirox (1) in an effort to produce organelle-targeting iron chelators with enhanced activity against A549 lung cancer cells. Derivative 8 was found to have improved antiproliferative activity relative to 1. Fluorescent cell imaging revealed that compound 8 preferentially localises within the lysosome. |
| WOS关键词 | IRON CHELATOR ; CANCER ; MECHANISMS ; HOMEOSTASIS ; AGENTS |
| 资助项目 | National Institutes of Health[CA 68682] ; Robert A. Welch Foundation[F-0018] ; NSFC[91853201] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; National Key Sci-Tech Special Projects of Infection Diseases of China[2018ZX10732202] ; International Cooperation Program of Shanghai Science and Technology Committee[17520750100] ; China Postdoctoral Science Foundation[2020M681196] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000649415500001 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/296644]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Li, Jia; He, Xiao-Peng; Sessler, Jonathan L. |
| 作者单位 | 1.Univ Texas Austin, Dept Chem, 105 E 24th St A5300, Austin, TX 78712 USA 2.East China Univ Sci & Technol, Key Lab Adv Mat, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Ctr Mat & Dynam Chem,Sch Chem & Mol Eng, 130 Meilong Rd, Shanghai 200237, Peoples R China 3.East China Univ Sci & Technol, Joint Int Res Lab Precis Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Ctr Mat & Dynam Chem,Sch Chem & Mol Eng, 130 Meilong Rd, Shanghai 200237, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Steinbrueck, Axel,Sedgwick, Adam C.,Han, Hai-Hao,et al. In vitro studies of deferasirox derivatives as potential organelle-targeting traceable anti-cancer therapeutics[J]. CHEMICAL COMMUNICATIONS,2021:4. |
| APA | Steinbrueck, Axel.,Sedgwick, Adam C..,Han, Hai-Hao.,Zhao, Michael Y..,Sen, Sajal.,...&Sessler, Jonathan L..(2021).In vitro studies of deferasirox derivatives as potential organelle-targeting traceable anti-cancer therapeutics.CHEMICAL COMMUNICATIONS,4. |
| MLA | Steinbrueck, Axel,et al."In vitro studies of deferasirox derivatives as potential organelle-targeting traceable anti-cancer therapeutics".CHEMICAL COMMUNICATIONS (2021):4. |
入库方式： OAI收割
来源：上海药物研究所
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