Ferric Ion Driven Assembly of Catalase-like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors
文献类型：期刊论文
| 作者 | Li, Yongxin1; Sun, Pan2; Zhao, Luyang3; Yan, Xuehai3; Ng, Dennis K. P.4; Lo, Pui-Chi1 |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2020-10-15 |
| 页码 | 12 |
| 关键词 | catalase hypoxia photodynamic therapy phthalocyanine self-assembly |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.202010005 |
| 英文摘要 | A facile approach to assemble catalase-like photosensitizing nanozymes with a self-oxygen-supplying ability was developed. The process involved Fe3+-driven self-assembly of fluorenylmethyloxycarbonyl (Fmoc)-protected amino acids. By adding a zinc(II) phthalocyanine-based photosensitizer (ZnPc) and the hypoxia-inducible factor 1 (HIF-1) inhibitor acriflavine (ACF) during the Fe3+-promoted self-assembly of Fmoc-protected cysteine (Fmoc-Cys), the nanovesicles Fmoc-Cys/Fe@Pc and Fmoc-Cys/Fe@Pc/ACF were prepared, which could be disassembled intracellularly. The released Fe(3+)could catalyze the transformation of H(2)O(2)enriched in cancer cells to oxygen efficiently, thereby ameliorating the hypoxic condition and promoting the photosensitizing activity of the released ZnPc. With an additional therapeutic component, Fmoc-Cys/Fe@Pc/ACF exhibited higher in vitro and in vivo photodynamic activities than Fmoc-Cys/Fe@Pc, demonstrating the synergistic effect of ZnPc and ACF. |
| WOS关键词 | PHOTODYNAMIC THERAPY ; HIGHLY EFFICIENT ; NANOPARTICLES ; STRATEGY ; ACID |
| 资助项目 | Research Grants Council of the Hong Kong Special Administrative Region[11300719] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000577647500001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | Research Grants Council of the Hong Kong Special Administrative Region |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/42383]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Yan, Xuehai; Ng, Dennis K. P.; Lo, Pui-Chi |
| 作者单位 | 1.City Univ Hong Kong, Dept Biomed Sci, Kowloon, Tat Chee Ave, Hong Kong, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, CAS Key Lab Green Proc & Engn, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 4.Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yongxin,Sun, Pan,Zhao, Luyang,et al. Ferric Ion Driven Assembly of Catalase-like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020:12. |
| APA | Li, Yongxin,Sun, Pan,Zhao, Luyang,Yan, Xuehai,Ng, Dennis K. P.,&Lo, Pui-Chi.(2020).Ferric Ion Driven Assembly of Catalase-like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,12. |
| MLA | Li, Yongxin,et al."Ferric Ion Driven Assembly of Catalase-like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumors".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020):12. |
入库方式： OAI收割
来源：过程工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。