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Superparamagnetic iron oxide nanoparticles conjugated with A beta oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer's Disease

文献类型：期刊论文

作者Liu, Xiao-ge1,2; Zhang, Lun1,2; Lu, Shuai2; Liu, Dong-qun2; Huang, Ya-ru1,2; Zhu, Jie2; Zhou, Wei-wei2; Yu, Xiao-lin2; Liu, Rui-tian2
刊名JOURNAL OF NANOBIOTECHNOLOGY
出版日期2020-11-07
卷号18期号:1页码:13
关键词Alzheimer's disease beta-Amyloid Oligomer Class A scavenger receptor Therapy
DOI10.1186/s12951-020-00723-1
英文摘要Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder. No disease-modifying strategy to prevent or delay AD progression currently exists. A beta oligomers (A beta Os), rather than monomers or fibrils, are considered as the primary neurotoxic species. Therapeutic approaches that direct against A beta Os and promote A beta clearance may have great value for AD treatment. Results: We here reported a multifunctional superparamagnetic iron oxide nanoparticle conjugated with A beta oligomer-specific scFv antibody W20 and class A scavenger receptor activator XD4 (W20/XD4-SPIONs). Besides the diagnostic value, W20/XD4-SPIONs retained the anti-A beta properties of W20 and XD4 by inhibiting A beta aggregation, attenuating A beta O-induced cytotoxicity and increasing microglial phagocytosis of A beta. When applied to APP/PS1 mice, W20/XD4-SPIONs significantly rescued cognitive deficits and alleviated neuropathology of AD mice. Conclusion: These results suggest that W20/XD4-SPIONs show therapeutic benefits for AD. In combination with the early diagnostic property, W20/XD4-SPIONs present as a promising agent for early-stage AD diagnosis and intervention.
WOS关键词AMYLOID HYPOTHESIS ; MICROGLIA ; RECOGNIZE ; CELLS
资助项目National Natural Science Foundation of China[81971610]
WOS研究方向Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
语种英语
出版者BMC
WOS记录号WOS:000590702000001
资助机构National Natural Science Foundation of China
源URL[http://ir.ipe.ac.cn/handle/122111/42608]  
专题中国科学院过程工程研究所
通讯作者Yu, Xiao-lin; Liu, Rui-tian
作者单位1.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Xiao-ge,Zhang, Lun,Lu, Shuai,et al. Superparamagnetic iron oxide nanoparticles conjugated with A beta oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer's Disease[J]. JOURNAL OF NANOBIOTECHNOLOGY,2020,18(1):13.
APA Liu, Xiao-ge.,Zhang, Lun.,Lu, Shuai.,Liu, Dong-qun.,Huang, Ya-ru.,...&Liu, Rui-tian.(2020).Superparamagnetic iron oxide nanoparticles conjugated with A beta oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer's Disease.JOURNAL OF NANOBIOTECHNOLOGY,18(1),13.
MLA Liu, Xiao-ge,et al."Superparamagnetic iron oxide nanoparticles conjugated with A beta oligomer-specific scFv antibody and class A scavenger receptor activator show therapeutic potentials for Alzheimer's Disease".JOURNAL OF NANOBIOTECHNOLOGY 18.1(2020):13.

入库方式： OAI收割

来源：过程工程研究所

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