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Efficient delivery of clay-based nanovaccines to the mouse spleen promotes potent anti-tumor immunity for both prevention and treatment of lymphoma

文献类型：期刊论文

作者Zhang, Ling-Xiao2,3,4,5,6; Jia, Ying-Bo3,4; Huang, Ya-Ru3,4; Liu, Hui-Na1,6; Sun, Xia-Mei3; Cai, Ting1,6; Liu, Rui-Tian3; Xu, Zhi Ping2
刊名NANO RESEARCH
出版日期2020-11-19
页码9
ISSN号1998-0124
关键词cancer immunotherapy nanovaccine layered double hydroxide targeted delivery to the spleen lymphoma
DOI10.1007/s12274-020-3175-0
英文摘要Cancer therapeutic nanovaccines are ideal tools to inhibit tumor growth and provide the body with continuous protecting immune surveillance. However, the conventional subcutaneous (SC) vaccination normally induces limited anti-tumor immune responses with low therapeutic efficacy. Herein, we devised clay-based nanovaccines and directly delivered them to the spleen via intravenous (IV) injection to induce the stronger anti-tumor immunity with higher efficacy for tumor prevention and treatment. The clay, i.e., layered double hydroxide (LDH) was prepared as nanoadjuvant with the average size from 77 to 285 nm and co-loaded with the model antigen ovalbumin (OVA) and bioadjuvant CpG to form CpG/OVA-LDH (CO-LDH) nanovaccines. We found that CO-LDH-215 (the size of LDH was 215 nm) promoted dendritic cells to present the most antigen, and moreover showed the highest spleen enrichment (similar to 1.67% of CO-LDH-215 enriched in the spleen at 24 h post IV injection). The in vivo immunologic data showed that CO-LDH-215 induced the most potent anti-tumor immune responses and completely prevented the growth of E.G7-OVA tumor in the mouse model. Furthermore, IV injected CO-LDH-215 nanovaccine more effectively delayed tumor growth than that SC injected, largely due to the direct and quick delivery of more nanovaccines to the spleen. This study demonstrates that the therapeutic efficacy of nanovaccines can be greatly enhanced by targeted delivery of nanovaccines to the spleen via the proper vaccination route.
WOS关键词DOUBLE HYDROXIDE NANOPARTICLES ; UPTAKE MECHANISM ; DENDRITIC CELLS ; CELLULAR UPTAKE ; MELANOMA TUMOR ; TRP2 PEPTIDE ; VACCINE ; PHARMACOKINETICS ; CANCER ; SIZE
资助项目International Partnership Program of Chinese Academy of Sciences[122111KYSB20180005] ; Australian Research Council (ARC) Discovery Project[DP190103486] ; Zhejiang Provincial Natural Science Foundation of China[LY19H160011] ; Ningbo Digestive System Clinical Medicine Research Center[2019A21003] ; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
出版者TSINGHUA UNIV PRESS
WOS记录号WOS:000590923600003
资助机构International Partnership Program of Chinese Academy of Sciences ; Australian Research Council (ARC) Discovery Project ; Zhejiang Provincial Natural Science Foundation of China ; Ningbo Digestive System Clinical Medicine Research Center ; Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province
源URL[http://ir.ipe.ac.cn/handle/122111/42656]  
专题中国科学院过程工程研究所
通讯作者Cai, Ting; Liu, Rui-Tian; Xu, Zhi Ping
作者单位1.Univ Chinese Acad Sci, Ningbo Inst Life & Hlth Ind, Ningbo 315010, Peoples R China
2.Univ Queensland, Australian Inst Bioengn & Nanotechnol, St Lucia, Qld 4072, Australia
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
5.Zhejiang Univ, Inst Pharmaceut, Coll Pharmaceut Sci, Hangzhou 310058, Peoples R China
6.Univ Chinese Acad Sci, Ningbo 2 Hosp, Hwa Mei Hosp, Ningbo 315010, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Ling-Xiao,Jia, Ying-Bo,Huang, Ya-Ru,et al. Efficient delivery of clay-based nanovaccines to the mouse spleen promotes potent anti-tumor immunity for both prevention and treatment of lymphoma[J]. NANO RESEARCH,2020:9.
APA Zhang, Ling-Xiao.,Jia, Ying-Bo.,Huang, Ya-Ru.,Liu, Hui-Na.,Sun, Xia-Mei.,...&Xu, Zhi Ping.(2020).Efficient delivery of clay-based nanovaccines to the mouse spleen promotes potent anti-tumor immunity for both prevention and treatment of lymphoma.NANO RESEARCH,9.
MLA Zhang, Ling-Xiao,et al."Efficient delivery of clay-based nanovaccines to the mouse spleen promotes potent anti-tumor immunity for both prevention and treatment of lymphoma".NANO RESEARCH (2020):9.

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来源：过程工程研究所

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