The Role of alpha-Synuclein Oligomers in Parkinson's Disease
文献类型：期刊论文
| 作者 | Du, Xiao-yu1,2 ; Xie, Xi-xiu1; Liu, Rui-tian1
|
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2020-11-01 |
| 卷号 | 21期号:22页码:17 |
| 关键词 | α -synuclein Parkinson’ s disease oligomers structure toxicity |
| DOI | 10.3390/ijms21228645 |
| 英文摘要 | alpha-synuclein (alpha-syn) is a protein associated with the pathogenesis of Parkinson's disease (PD), the second most common neurodegeneration disease with no effective treatment. However, how alpha-syn drives the pathology of PD remains elusive. Recent studies suggest that alpha-syn oligomers are the primary cause of neurotoxicity and play a critical role in PD. In this review, we discuss the process of alpha-syn oligomers formation and the current understanding of the structures of oligomers. We also describe seed and propagation effects of oligomeric forms of alpha-syn. Then, we summarize the mechanism by which alpha-syn oligomers exert neurotoxicity and promote neurodegeneration, including mitochondrial dysfunction, endoplasmic reticulum stress, proteostasis dysregulation, synaptic impairment, cell apoptosis and neuroinflammation. Finally, we investigate treatment regimens targeting alpha-syn oligomers at present. Further research is needed to understand the structure and toxicity mechanism of different types of oligomers, so as to provide theoretical basis for the treatment of PD. |
| WOS关键词 | IN-VIVO ; NEURONAL DEGENERATION ; ACCUMULATION ; TOXICITY ; BRAIN ; DEGRADATION ; ANTIBODIES ; STRESS ; MODEL ; NEURODEGENERATION |
| 资助项目 | National Natural Science Foundation of China[81971073] ; National Natural Science Foundation of China[81903531] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000594886400001 |
| 出版者 | MDPI |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/42752]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Liu, Rui-tian |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Xiao-yu,Xie, Xi-xiu,Liu, Rui-tian. The Role of alpha-Synuclein Oligomers in Parkinson's Disease[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2020,21(22):17. |
| APA | Du, Xiao-yu,Xie, Xi-xiu,&Liu, Rui-tian.(2020).The Role of alpha-Synuclein Oligomers in Parkinson's Disease.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,21(22),17. |
| MLA | Du, Xiao-yu,et al."The Role of alpha-Synuclein Oligomers in Parkinson's Disease".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 21.22(2020):17. |
入库方式： OAI收割
来源：过程工程研究所
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