A Reactive Oxygen Species-Responsive Poly(amino acids) Nanoparticle Loading Doxorubicin for Glioblastoma Multiforme Treatment
文献类型：期刊论文
| 作者 | Shi, Zhuyan; Yang, Jun; Liu, Linying; Lu, Zhiguo; Ji, Weihong; Shen, Jie; Zhang, Xin2 |
| 刊名 | JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
 |
| 出版日期 | 2020-06-01 |
| 卷号 | 16期号:6页码:931-940 |
| 关键词 | Poly(amino acids) Drug Delivery ROS-Responsive Release Doxorubicin Glioblastoma Multiforme |
| ISSN号 | 1550-7033 |
| DOI | 10.1166/jbn.2020.2947 |
| 英文摘要 | Amino acids are significant for human life and therefore considered as the crucial nutrients for human body with high biosafety. Due to their high biocompatibilities and various physicochemical properties, their polymers can be applied to construct drug delivery systems for various diseases' treatments. Among them, glioblastoma multiforme received special attention and numerous efforts regarding to nanotechnology were developed to treat such tumor. However, the biosafety of the delivering materials in those efforts arises as a critical issue in consideration of the weak patients. Therefore, a ROSresponsive nanoparticle (DOX@PLSPL) with poly(amino acids) encapsulating doxorubicin was developed for glioblastoma multiforme treatment. DOX@PLSPL was constructed by poly-lysine and poly-leucine with high biocompatibility. The high doxorubicin encapsulation efficiency and the controlled release manner of DOX@PLSPL ensured its high anti-tumor effect. Totally, this DOX@PLSPL can be used as a promising drug delivery system for glioblastoma multiforme treatments. |
| WOS关键词 | MALIGNANT GLIOMAS ; BRAIN ; DELIVERY ; RELEASE ; DRUGS |
| 资助项目 | National High Technology Research and Development Program[2016YFA0200303] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[51573188] ; National Natural Science Foundation of China[21875254] ; Beijing Natural Science Foundation[L172046] ; Beijing Natural Science Foundation[2192057] |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000589896300002 |
| 出版者 | AMER SCIENTIFIC PUBLISHERS |
| 资助机构 | National High Technology Research and Development Program ; National Natural Science Foundation of China ; Beijing Natural Science Foundation |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/42782]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Zhang, Xin |
| 作者单位 | 1.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Zhuyan,Yang, Jun,Liu, Linying,et al. A Reactive Oxygen Species-Responsive Poly(amino acids) Nanoparticle Loading Doxorubicin for Glioblastoma Multiforme Treatment[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2020,16(6):931-940. |
| APA | Shi, Zhuyan.,Yang, Jun.,Liu, Linying.,Lu, Zhiguo.,Ji, Weihong.,...&Zhang, Xin.(2020).A Reactive Oxygen Species-Responsive Poly(amino acids) Nanoparticle Loading Doxorubicin for Glioblastoma Multiforme Treatment.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,16(6),931-940. |
| MLA | Shi, Zhuyan,et al."A Reactive Oxygen Species-Responsive Poly(amino acids) Nanoparticle Loading Doxorubicin for Glioblastoma Multiforme Treatment".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 16.6(2020):931-940. |
入库方式： OAI收割
来源：过程工程研究所
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