Synthetic Particles for Cancer Vaccines: Connecting the Inherent Supply Chain
文献类型：期刊论文
| 作者 | Xia, Yufei1,2,3; Song, Tiantian3; Hu, Yuning1,2,3; Ma, Guanghui1,2,3 |
| 刊名 | ACCOUNTS OF CHEMICAL RESEARCH
 |
| 出版日期 | 2020-10-20 |
| 卷号 | 53期号:10页码:2068-2080 |
| ISSN号 | 0001-4842 |
| DOI | 10.1021/acs.accounts.0c00336 |
| 英文摘要 | Cancer vaccines have opened a new paradigm for safe and effective antitumor therapy, but they still suffer from shortcomings such as insufficient immunogenicity and immune tolerance, which seldom makes them the first choice in clinic. In fact, similar to providing a high-end product, a robust antitumor effect depends on the inherent supply chain, which attains, processes, and presents tumor-associated antigens via antigen presenting cells to T cells, which then leads to lysis of the cancer cells to release more antigens to complete the supply chain. Under these circumstances, the failure of cancer vaccines can be treated as a blockade or chain rupture. Thus, for effective tumor treatment, the key is to rationally design logistic systems to restore the supply chain. Under these circumstances, this Account summarizes our recent attempts to exploit the immunogenic trait of synthetic particles to enhance the distribution, presentation, and immune activations of the whole priming process in cancer vaccines: (1) Raw material (tumor antigen/signals) procurement: We illustrated the efforts to deliver antigens to antigen presenting cells (APCs) and draining lymph nodes for potent internalizations, and put more emphasis on the structural effect of sizes, charges, shapes, and assembly strategies for the antigen depot, lymph node transfer, and APC endocytosis. (2) Manufacture of cytotoxic T lymphocytes (CTLs) via APC recognition and presentation: We centered on exploiting the softness of two-dimensional graphene and Pickering emulsions to dynamically potentiate the immune recognition, and demonstrating the recent advances in lysosome escape strategies for enhanced antigen cross-presentations. (3) Marketing the accumulations of CTLs and the reversal of an immunosuppressive microenvironment within the tumor: We demonstrated the previous attempts to inherently cultivate the tumor tropism of the T cells via the multiantigenic repertoire and discussed the advances and challenges of combinatory cancer vaccines with an immune checkpoint blockade to reinforce the antitumor efficacy. Collectively, this Account aims to illustrate the potential of the particulate cancer vaccines to recapitalize the inherent host immune responses for the maximum antitumor effect. And by integrating the antitumor supply chain, optimized synthetic particles may shed light on the development of safe and effective particulate cancer vaccines. |
| WOS关键词 | NANOPARTICLES ; RESPONSES ; IMPROVE ; CELLS ; ADJUVANTICITY ; SIZE |
| 资助项目 | Foundation for Innovative Research Groups of the National Natural Science Foundation of China[21821005] ; Pilot Project of Chinese Academy of Sciences[XDB29040303] ; "From 0 to 1" Original Innovation Project of Basic Frontier Scientific Research Program of Chinese Academy of Sciences[2020000071] ; Beijing Nova Program[Z201100006820139] ; Youth Project of National Natural Science Foundation of China[21908229] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2020000053] ; Key External Cooperation Program of Chinese Academy of Sciences[122111KYSB20180021] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000584415900005 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | Foundation for Innovative Research Groups of the National Natural Science Foundation of China ; Pilot Project of Chinese Academy of Sciences ; "From 0 to 1" Original Innovation Project of Basic Frontier Scientific Research Program of Chinese Academy of Sciences ; Beijing Nova Program ; Youth Project of National Natural Science Foundation of China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Key External Cooperation Program of Chinese Academy of Sciences |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/42792]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Ma, Guanghui |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Innovat Acad Green Manufacture, Beijing 100190, Peoples R China 3.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xia, Yufei,Song, Tiantian,Hu, Yuning,et al. Synthetic Particles for Cancer Vaccines: Connecting the Inherent Supply Chain[J]. ACCOUNTS OF CHEMICAL RESEARCH,2020,53(10):2068-2080. |
| APA | Xia, Yufei,Song, Tiantian,Hu, Yuning,&Ma, Guanghui.(2020).Synthetic Particles for Cancer Vaccines: Connecting the Inherent Supply Chain.ACCOUNTS OF CHEMICAL RESEARCH,53(10),2068-2080. |
| MLA | Xia, Yufei,et al."Synthetic Particles for Cancer Vaccines: Connecting the Inherent Supply Chain".ACCOUNTS OF CHEMICAL RESEARCH 53.10(2020):2068-2080. |
入库方式： OAI收割
来源：过程工程研究所
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