Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing alpha-synuclein and immune activation of Parkinson's disease
文献类型：期刊论文
| 作者 | Liu, Linying1,2,3; Li, Yan1,2; Peng, Huan1,2; Liu, Ruiyuan1,2; Ji, Weihong1,2; Shi, Zhuyan1,2; Shen, Jie1,2; Ma, Guanghui1; Zhang, Xin1,2 |
| 刊名 | SCIENCE ADVANCES
 |
| 出版日期 | 2020-12-01 |
| 卷号 | 6期号:50页码:11 |
| ISSN号 | 2375-2548 |
| DOI | 10.1126/sciadv.aba3967 |
| 英文摘要 | The most critical problem in the treatment of neurodegenerative diseases is brain neuronal protection, which can be overcome by clearing pathological substances and regulating the immune environment. In the above treatment strategies, the traditional poor drug delivery problem is inevitable. Here, we show an engineering core-shell hybrid system named rabies virus glycoprotein (RVG) peptide-modified exosome (EXO) curcumin/phenylboronic acid-poly(2-(dimethylamino)ethyl acrylate) nanoparticle/small interfering RNA targeting SNCA (REXO-C/ANP/S). It is a nanoscavenger for clearing alpha-synuclein aggregates and reducing their cytotoxicity in Parkinson's disease neurons. The motor behavior of Parkinson's disease mice is substantially improved after REXO-C/ANP/S treatment. In particular, we demonstrate that REXO-C/ANP/S is also a nanoscavenger for clearing immune activation due to its natural immature dendritic cell EXO coating. Our findings show that REXO-C/ANP/S may serve as a platform for neurodegenerative diseases treatment. |
| WOS关键词 | DENDRITIC CELLS ; SIRNA DELIVERY ; MOTOR DYSFUNCTION ; CURCUMIN ; BRAIN ; AGGREGATION ; INDUCTION ; IL-10 |
| 资助项目 | Beijing Nova Program[Z201100006820140] ; National High Technology Research and Development Program[2016YFA0200303] ; National Natural Science Foundation of China[21905283] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; Beijing Natural Science Foundation[2192057] ; Beijing Natural Science Foundation[L172046] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000599903600002 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| 资助机构 | Beijing Nova Program ; National High Technology Research and Development Program ; National Natural Science Foundation of China ; Beijing Natural Science Foundation |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/42840]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Zhang, Xin |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Beijing Polytech, Coll Bioengn, Beijing 100176, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Linying,Li, Yan,Peng, Huan,et al. Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing alpha-synuclein and immune activation of Parkinson's disease[J]. SCIENCE ADVANCES,2020,6(50):11. |
| APA | Liu, Linying.,Li, Yan.,Peng, Huan.,Liu, Ruiyuan.,Ji, Weihong.,...&Zhang, Xin.(2020).Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing alpha-synuclein and immune activation of Parkinson's disease.SCIENCE ADVANCES,6(50),11. |
| MLA | Liu, Linying,et al."Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing alpha-synuclein and immune activation of Parkinson's disease".SCIENCE ADVANCES 6.50(2020):11. |
入库方式： OAI收割
来源：过程工程研究所
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