Sprayed Pickering emulsion with high antibacterial activity for wound healing
文献类型：期刊论文
| 作者 | Bao, Xieru2,4; Wu, Jie1,2,3,4; Ma, Guanghui1,2,3,4 |
| 刊名 | PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL
 |
| 出版日期 | 2020-10-01 |
| 卷号 | 30期号:5页码:669-676 |
| 关键词 | Pickering emulsion Wound healing Chitosan nanoparticles High viscosity Antibacterial activity |
| ISSN号 | 1002-0071 |
| DOI | 10.1016/j.pnsc.2020.08.001 |
| 英文摘要 | Effective treatment of wound injuries can prevent infections and promote healing. In this work, a sprayed Pickering emulsion composed of chitosan nanoparticles, tea tree oil and curcumin was formulated. The shear thinning behaviour allowed this Pickering emulsion to spray even with a high viscosity provided by the aqueous phase containing chitosan nanoparticles. Moreover, the Pickering emulsion could recover to the high viscosity after spraying onto the wounds, leading to the long residence time and intimate contact. In addition, the Pickering emulsion provided a carrier to encapsulate the tea tree oil, which caused sustained-release effects and further strengthened tea tree oil's antibacterial activity towards the Gram-negative Escherichia coli (E. coli), Gram-positive Staphylococcus aureus (S. aureus) and Gram-positive methicillin-resistant Staphylococcus aureus (MRSA). Besides, this multi-phase system offered a platform to load with hydrophobic curcumin, leading to better synergistic healing effects. Meanwhile, the Pickering emulsion avoided the irritation and toxicity related to surfactants, which was far safer than the classical emulsion especially when used in the defective skin. All these excellent properties endowed this sprayed Pickering emulsion with promising prospects for wound healing. |
| WOS关键词 | TEA TREE OIL ; IN-VITRO ; HYDROGEL ; SKIN ; PARTICLES ; NANOPARTICLES ; MEMBRANE ; DELIVERY ; SYSTEM |
| 资助项目 | National Key R&D Program of China, China[2018YFC0311303] ; Key Research Program of the Chinese Academy of Sciences, China[KFZD-SW-218] ; International Cooperation Project of the Chinese Academy of Sciences, China[122111KYSB20180021] ; National Natural Science Foundation of China[21776287] |
| WOS研究方向 | Materials Science ; Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000604439100004 |
| 出版者 | ELSEVIER SCIENCE INC |
| 资助机构 | National Key R&D Program of China, China ; Key Research Program of the Chinese Academy of Sciences, China ; International Cooperation Project of the Chinese Academy of Sciences, China ; National Natural Science Foundation of China |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/43039]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Wu, Jie; Ma, Guanghui |
| 作者单位 | 1.Jiangsu Natl Synerget Innovat Ctr Adv Mat, Nanjing, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, PLA Key Lab Biopharmaceut Prod & Formulat Engn, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bao, Xieru,Wu, Jie,Ma, Guanghui. Sprayed Pickering emulsion with high antibacterial activity for wound healing[J]. PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL,2020,30(5):669-676. |
| APA | Bao, Xieru,Wu, Jie,&Ma, Guanghui.(2020).Sprayed Pickering emulsion with high antibacterial activity for wound healing.PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL,30(5),669-676. |
| MLA | Bao, Xieru,et al."Sprayed Pickering emulsion with high antibacterial activity for wound healing".PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL 30.5(2020):669-676. |
入库方式： OAI收割
来源：过程工程研究所
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