中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 过程工程研究所
  3. 中国科学院过程工程研究所
Black phosphorus quantum dots encapsulated in anionic waterborne polyurethane nanoparticles for enhancing stability and reactive oxygen species generation for cancer PDT/PTT therapy

文献类型：期刊论文

作者Lu, Fengying2,3; Li, Zhengjun2; Kang, Yong1,2; Su, Zhiguo2; Yu, Rong3; Zhang, Songping2
刊名JOURNAL OF MATERIALS CHEMISTRY B
出版日期2020-12-14
卷号8期号:46页码:10650-10661
ISSN号2050-750X
DOI10.1039/d0tb02101f
英文摘要Black phosphorus quantum dots (BPQDs) with excellent biocompatibility, outstanding photothermal and photodynamic efficacies have attracted significant attention in cancer therapy. However, the low environmental stability and poor dispersity of BPQDs limit their practical applications. In the present work, biocompatible anionic waterborne polyurethane (WPU) nanoparticles were synthesized from castor oil to encapsulate the BPQDs. The WPU-BPQDs with a BPQDs loading capacity of about 13.8% (w/w) exhibited significantly improved dispersion and environmental stability without affecting the photothermal efficiency of BPQDs. Intriguingly, it was found that WPU encapsulation led to significant enhancement in the reactive oxygen species (ROS) generation of BPQDs, which indicated the enhanced photodynamic efficacy of the encapsulated BPQDs as compared to the bare BPQDs. The effect of solution pH on the ROS generation efficiency of BPQDs and the pH variation caused by BPQDs degradation was then investigated to explore the possible mechanism. In acidic solution, ROS generation was suppressed, while BPQDs degradation led to the acidification of the solution. Fortunately, after being encapsulated inside the WPU nanoparticles, the degradation rate of BPQDs became slower, while the acidic environment around BPQDs was favorably regulated by WPU nanoparticles having a special electrochemical double layer consisting of interior COO- and exterior NH(Et-3)(+), thus endowing the WPU-BPQDs-boosted production of ROS as compared to the bare BPQDs. Considering the undesired acidic tumor environment, this unique pH regulation effect of WPU-BPQDs would be beneficial for in vivo photodynamic efficacy. Both in vitro and in vivo experiments showed that WPU-BPQDs could effectively improve photodynamic therapy (PDT) and maintain outstanding photothermal therapy (PTT) effects. Together with the excellent dispersity, biocompatibility, and easy biodegradability, WPU-BPQDs can be a promising agent for PDT/PTT cancer treatments.
WOS关键词PHOTOTHERMAL THERAPY ; DRUG-DELIVERY ; NANOSHEETS ; MICELLES ; NANOCARRIERS ; DESIGN
资助项目National Natural Science Foundation of China[21676276]
WOS研究方向Materials Science
语种英语
WOS记录号WOS:000608190300017
出版者ROYAL SOC CHEMISTRY
资助机构National Natural Science Foundation of China
源URL[http://ir.ipe.ac.cn/handle/122111/43134]  
专题中国科学院过程工程研究所
通讯作者Yu, Rong; Zhang, Songping
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Sichuan Univ, West China Sch Pharm, Minist Educ, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Peoples R China
推荐引用方式
GB/T 7714		 Lu, Fengying,Li, Zhengjun,Kang, Yong,et al. Black phosphorus quantum dots encapsulated in anionic waterborne polyurethane nanoparticles for enhancing stability and reactive oxygen species generation for cancer PDT/PTT therapy[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020,8(46):10650-10661.
APA Lu, Fengying,Li, Zhengjun,Kang, Yong,Su, Zhiguo,Yu, Rong,&Zhang, Songping.(2020).Black phosphorus quantum dots encapsulated in anionic waterborne polyurethane nanoparticles for enhancing stability and reactive oxygen species generation for cancer PDT/PTT therapy.JOURNAL OF MATERIALS CHEMISTRY B,8(46),10650-10661.
MLA Lu, Fengying,et al."Black phosphorus quantum dots encapsulated in anionic waterborne polyurethane nanoparticles for enhancing stability and reactive oxygen species generation for cancer PDT/PTT therapy".JOURNAL OF MATERIALS CHEMISTRY B 8.46(2020):10650-10661.

入库方式： OAI收割

来源：过程工程研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。