Self-Activatable Photo-Extracellular Vesicle for Synergistic Trimodal Anticancer Therapy
文献类型：期刊论文
| 作者 | Ding, Jingjing2; Lu, Guihong1; Nie, Weidong2; Huang, Li-Li2; Zhang, Yahui2; Fan, Wenlin2; Wu, Guanghao2; Liu, Houli2; Xie, Hai-Yan2 |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2021-01-12 |
| 页码 | 12 |
| 关键词 | chemotherapy extracellular vesicle immunotherapy photodynamic therapy tumor microenvironment |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.202005562 |
| 英文摘要 | Extracellular vesicles (EVs) hold great potential in both disease treatment and drug delivery. However, accurate drug release from EVs, as well as the spontaneous treatment effect cooperation of EVs and drugs at target tissues, is still challenging. Here, an engineered self-activatable photo-EV for synergistic trimodal anticancer therapy is reported. M1 macrophage-derived EVs (M1 EVs) are simultaneously loaded with bis[2,4,5-trichloro-6-(pentyloxycarbonyl) phenyl] oxalate (CPPO), chlorin e6 (Ce6), and prodrug aldoxorubicin (Dox-EMCH). After administration, the as-prepared system actively targets tumor cells because of the tumor-homing capability of M1 EVs, wherein M1 EVs repolarize M2 to M1 macrophages, which not only display immunotherapy effects but also produce H2O2. The reaction between H2O2 and CPPO generates chemical energy that activates Ce6, creating both chemiluminescence for imaging and singlet oxygen (O-1(2)) for photodynamic therapy (PDT). Meanwhile, O-1(2)-induced membrane rupture leads to the release of Dox-EMCH, which is then activated and penetrates the deep hypoxic areas of tumors. The synergism of immunotherapy, PDT, and chemotherapy results in potent anticancer efficacy, showing great promise to fight cancers. |
| WOS关键词 | TUMOR-ASSOCIATED MACROPHAGES ; HYDROGEN-PEROXIDE ; EXOSOMES ; DRUG ; NANOPARTICLES ; DELIVERY ; CHEMILUMINESCENCE ; PACLITAXEL ; PHENOTYPE |
| 资助项目 | National Science Foundation of China[21874011] ; National Science Foundation of China[91859213] ; National Science Foundation of China[22025401] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000606809100001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | National Science Foundation of China |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/43154]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Xie, Hai-Yan |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ding, Jingjing,Lu, Guihong,Nie, Weidong,et al. Self-Activatable Photo-Extracellular Vesicle for Synergistic Trimodal Anticancer Therapy[J]. ADVANCED MATERIALS,2021:12. |
| APA | Ding, Jingjing.,Lu, Guihong.,Nie, Weidong.,Huang, Li-Li.,Zhang, Yahui.,...&Xie, Hai-Yan.(2021).Self-Activatable Photo-Extracellular Vesicle for Synergistic Trimodal Anticancer Therapy.ADVANCED MATERIALS,12. |
| MLA | Ding, Jingjing,et al."Self-Activatable Photo-Extracellular Vesicle for Synergistic Trimodal Anticancer Therapy".ADVANCED MATERIALS (2021):12. |
入库方式： OAI收割
来源：过程工程研究所
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