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The immunodominant and neutralization linear epitopes for SARS-CoV-2

文献类型：期刊论文

作者Lu, Shuai5,6; Xie, Xi-xiu5,6; Zhao, Lei4; Wang, Bin5,6; Zhu, Jie5,6; Yang, Ting-rui5,6; Yang, Guang-wen3; Ji, Mei6; Lv, Cui-ping6; Xue, Jian4
刊名CELL REPORTS
出版日期2021-01-26
卷号34期号:4页码:12
ISSN号2211-1247
DOI10.1016/j.celrep.2020.108666
英文摘要Although vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are under development, the antigen epitopes on the virus and their immunogenicity are poorly understood. Here, we simulate the 3D structures and predict the B cell epitopes on the spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins of SARS-CoV-2 using structure-based approaches and validate epitope immunogenicity by immunizing mice. Almost all 33 predicted epitopes effectively induce antibody production, six of these are immunodominant epitopes in individuals, and 23 are conserved within SARS-CoV-2, SARS-CoV, and bat coronavirus RaTG13. We find that the immunodominant epitopes of individuals with domestic (China) SARS-CoV-2 are different from those of individuals with imported (Europe) SARS-CoV-2, which may be caused by mutations on the S (G614D) and N proteins. Importantly, we find several epitopes on the S protein that elicit neutralizing antibodies against D614 and G614 SARS-CoV-2, which can contribute to vaccine design against coronaviruses.
WOS关键词CORONAVIRUS ; ANTIBODIES ; PEPTIDES ; VACCINE
资助项目National Natural Science Foundation of China[81971610] ; National Natural Science Foundation of China[81971073] ; National Natural Science Foundation of China[81903531] ; National Science and Technology Major Projects of New Drugs[2018ZX09733001-001-008] ; Innovation Academy for Green Manufacture, Chinese Academy of Sciences[IAGM2020C29] ; Zhejiang University Special Scientific Research Fund for COVID-19 Prevention and Control[2020XGZX075]
WOS研究方向Cell Biology
语种英语
出版者CELL PRESS
WOS记录号WOS:000613631500008
资助机构National Natural Science Foundation of China ; National Science and Technology Major Projects of New Drugs ; Innovation Academy for Green Manufacture, Chinese Academy of Sciences ; Zhejiang University Special Scientific Research Fund for COVID-19 Prevention and Control
源URL[http://ir.ipe.ac.cn/handle/122111/43433]  
专题中国科学院过程工程研究所
通讯作者Jiang, Chun-guo; Liu, Rui-tian
作者单位1.Univ Sci & Technol, Hefei 230026, Peoples R China
2.Chinese Univ Hong Kong, Shenzhen 518172, Peoples R China
3.Tsinghua Univ, Dept Comp Sci & Technol, Beijing 100084, Peoples R China
4.Shijiazhuang Fifth Hosp, Dept Internal Med 2, Shijiazhuang 050021, Hebei, Peoples R China
5.Chinese Acad Sci, Innovat Acad Green Manufacture, Beijing 100190, Peoples R China
6.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
7.Capital Med Univ, Beijing Inst Resp Med, Dept Resp & Crit Care Med, Beijing Chaoyang Hosp, Beijing 100020, Peoples R China
8.Guangdong Prov Ctr Dis Control & Prevent, Guangzhou 511430, Peoples R China
推荐引用方式
GB/T 7714		 Lu, Shuai,Xie, Xi-xiu,Zhao, Lei,et al. The immunodominant and neutralization linear epitopes for SARS-CoV-2[J]. CELL REPORTS,2021,34(4):12.
APA Lu, Shuai.,Xie, Xi-xiu.,Zhao, Lei.,Wang, Bin.,Zhu, Jie.,...&Liu, Rui-tian.(2021).The immunodominant and neutralization linear epitopes for SARS-CoV-2.CELL REPORTS,34(4),12.
MLA Lu, Shuai,et al."The immunodominant and neutralization linear epitopes for SARS-CoV-2".CELL REPORTS 34.4(2021):12.

入库方式： OAI收割

来源：过程工程研究所

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