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A perspective review on mixing effect for modeling and simulation of reactive and antisolvent crystallization processes

文献类型：期刊论文

作者Qu, Yanli2,3; Cheng, Jingcai1,2; Mao, Zai-Sha2; Yang, Chao1,2,3
刊名REACTION CHEMISTRY & ENGINEERING
出版日期2021-02-01
卷号6期号:2页码:183-196
ISSN号2058-9883
DOI10.1039/d0re00223b
英文摘要Reactive and antisolvent crystallization processes are efficient techniques for the production of fine chemicals and pharmaceuticals. These processes are usually characterized by high levels of supersaturation and fast primary crystallization kinetics. Understanding the mixing mechanism and its interaction with various crystallization phenomena is advantageous for achieving robust control of these crystallization processes and the desired crystal properties. Much modeling effort has been devoted to accounting for the combined effects of mixing on various scales and the complicated kinetic phenomena involved in these processes as complementary to experimental investigations. This article provides a review on the numerical simulation of reactive and antisolvent crystallization processes with an emphasis on modeling the mixing effect. Relevant Lagrangian mechanistic micromixing models and probability density function (PDF) approaches are introduced followed by simulation examples from the literature. Various examples are categorized into four groups according to the different coupling between mixing, crystallization kinetics and flow field. Also, some suggestions on further model development are given to enhance their predictive performances and broaden the range of application.
资助项目National Natural Science Foundation of China[21938009] ; National Natural Science Foundation of China[21776284] ; National Natural Science Foundation of China[91934301] ; National Key Research and Development Program[2019YFC1904204] ; External Cooperation Program of BIC, Chinese Academy of Sciences[122111KYSB20190032] ; Key Research Program of Frontier Sciences, CAS[QYZDJ-SSW-JSC030]
WOS研究方向Chemistry ; Engineering
语种英语
WOS记录号WOS:000616272700001
出版者ROYAL SOC CHEMISTRY
资助机构National Natural Science Foundation of China ; National Key Research and Development Program ; External Cooperation Program of BIC, Chinese Academy of Sciences ; Key Research Program of Frontier Sciences, CAS
源URL[http://ir.ipe.ac.cn/handle/122111/43647]  
专题中国科学院过程工程研究所
通讯作者Cheng, Jingcai; Yang, Chao
作者单位1.Chinese Acad Sci, Innovat Acad Green Manufacture, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, CAS Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Qu, Yanli,Cheng, Jingcai,Mao, Zai-Sha,et al. A perspective review on mixing effect for modeling and simulation of reactive and antisolvent crystallization processes[J]. REACTION CHEMISTRY & ENGINEERING,2021,6(2):183-196.
APA Qu, Yanli,Cheng, Jingcai,Mao, Zai-Sha,&Yang, Chao.(2021).A perspective review on mixing effect for modeling and simulation of reactive and antisolvent crystallization processes.REACTION CHEMISTRY & ENGINEERING,6(2),183-196.
MLA Qu, Yanli,et al."A perspective review on mixing effect for modeling and simulation of reactive and antisolvent crystallization processes".REACTION CHEMISTRY & ENGINEERING 6.2(2021):183-196.

入库方式： OAI收割

来源：过程工程研究所

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