Beta-Elemene Reduces the Malignancy of Non-Small Cell Lung Cancer by Enhancing C3orf21 Expression
文献类型：期刊论文
| 作者 | Cai, Hu1; Ren, Lili1; Wang, Ying2; Zhang, Yongjun1 |
| 刊名 | FRONTIERS IN ONCOLOGY
 |
| 出版日期 | 2021-05-07 |
| 卷号 | 11 |
| 关键词 | elemene injection C3orf21 non-small cell lung cancer malignancy mechanisms |
| ISSN号 | 2234-943X |
| DOI | 10.3389/fonc.2021.571476 |
| 通讯作者 | Zhang, Yongjun(zhangyj@zjcc.org.cn) |
| 英文摘要 | Background Beta-elemene has potent anti-tumor effect, but its anti-tumor mechanism remains unclear. Chromosome 3 open reading frame 21 (C3orf21) acts as a tumor suppressor. This study tested whether the anti-tumor effect of beta-elemene was associated with modulating C3orf21 expression in non-small cell lung cancer (NSCLC). Materials and Methods The impact of beta-elemene on C3orf21 expression in NSCLC cells was quantified. The stable C3orf21 silencing A549 and over-expressing PC-9 cells were established and their effects on the beta-elemene-attenuated proliferation, wound healing and invasion of NSCLC cells as well as the expression of key regulators and signal events were determined. Results Beta-elemene significantly up-regulated C3orf21 expression in NSCLC cells. Beta-elemene treatment significantly attenuated the proliferation, wound healing and invasion of NSCLC cells, which were significantly mitigated by C3orf21 silencing, but enhanced by C3orf21 over-expression. Similar patterns of beta-elemene-modulated cyclinD1, c-Myc, COX2, MMP2, MMP9, VEGF, PTEN and Notch1 expression were detected in NSCLC cells. Conclusions Such data indicated that beta-elemene treatment attenuated the malignancy of NSCLC cells by up-regulating C3orf21 expression. Our findings may provide new mechanisms underlying the pharmacological action of beta-elemene. |
| 资助项目 | Zhejiang Provincial Medical and Health Scientific and Technical Foundation[2017171306] ; Zhejiang Provincial Medical and Health Scientific and Technical Foundation[2018KY296] ; Zhejiang Provincial Medical and Health Scientific and Technical Foundation[2020KY470] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000652342000001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | Zhejiang Provincial Medical and Health Scientific and Technical Foundation |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/122155]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Zhang, Yongjun |
| 作者单位 | 1.Chinese Acad Sci, Canc Hosp, Inst Basic Med & Canc IBMC,Zhejiang Canc Hosp, Dept Integrat Tradit Chinese & Western Med,Univ C, Hangzhou, Peoples R China 2.Chinese Acad Sci, Dept Gynecol Oncol, Canc Hosp, Univ Chinese Acad Sci,Zhejiang Canc Hosp,Inst Bas, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cai, Hu,Ren, Lili,Wang, Ying,et al. Beta-Elemene Reduces the Malignancy of Non-Small Cell Lung Cancer by Enhancing C3orf21 Expression[J]. FRONTIERS IN ONCOLOGY,2021,11. |
| APA | Cai, Hu,Ren, Lili,Wang, Ying,&Zhang, Yongjun.(2021).Beta-Elemene Reduces the Malignancy of Non-Small Cell Lung Cancer by Enhancing C3orf21 Expression.FRONTIERS IN ONCOLOGY,11. |
| MLA | Cai, Hu,et al."Beta-Elemene Reduces the Malignancy of Non-Small Cell Lung Cancer by Enhancing C3orf21 Expression".FRONTIERS IN ONCOLOGY 11(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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