Silver nanoparticles protect against arsenic induced genotoxicity via attenuating arsenic bioaccumulation and elevating antioxidation in mammalian cells
文献类型：期刊论文
| 作者 | Wang, Xue2,3,6 ; Nie, Yaguang1,4; Si, Bo2,3; Wang, Tong2,3; Hei, Tom K.5; Du, Hua2,3; Zhao, Guoping2,3; Chen, Shaopeng2,3; Xu, An1,2,3,4,6; Liu, Yun2,3
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| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
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| 出版日期 | 2021-07-05 |
| 卷号 | 413 |
| ISSN号 | 0304-3894 |
| 关键词 | Arsenic (As) Silver nanoparticles (AgNPs) Detoxification Bioaccumulation Antioxidation |
| DOI | 10.1016/j.jhazmat.2021.125287 |
| 通讯作者 | Xu, An(anxu@ipp.ac.cn) ; Liu, Yun(yliu@itb.ac.cn) |
| 英文摘要 | Arsenic (As) and its compounds have been classified as Group I carcinogenic agents by the International Agency for Research on Cancer (IARC); however, there is few specific and efficient antidotes used for As detoxification. The present study aimed to investigate the protective effects of silver nanoparticles (AgNPs) at non-toxic concentrations on As(III) induced genotoxicity and the underlying mechanism. Our data showed that AgNPs pretreatment significantly inhibited the generation of phosphorylated histone H2AX (?-H2AX, marker of nuclear DNA double strand breaks) and the mutation frequencies induced by As(III) exposure. Atomic fluorescence spectrometer (AFS) and laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) analysis revealed that the intracellular accumulation of As(III) in human-hamster hybrid AL cells was declined by AgNPs via suppressing the expression of specific As(III)-binding protein (Gal-1). Moreover, the activities of antioxidant enzymes were greatly up-regulated by AgNPs, which eventually inhibited the generation of reactive oxygen species (ROS) induced by As(III) and the downstream stress-activated protein kinases/c-Jun amino-terminal kinases (SAPK/JNK) signaling pathway. These results provided clear evidence that AgNPs dramatically suppressed the genotoxic response of As(III) in mammalian cells via decreasing As(III) bioaccumulation and elevating intracellular antioxidation, which might provide a new clue for AgNPs applications in As(III) detoxification. |
| WOS关键词 | INDUCED DNA-DAMAGE ; OXIDATIVE STRESS ; JOINT TOXICITY ; ZINC-OXIDE ; ACTIVATION ; CYTOTOXICITY ; PREVENTION ; MUTAGENICITY ; REMEDIATION ; MECHANISMS |
| 资助项目 | National Natural Science Foundation of China[22076191] ; National Natural Science Foundation of China[21677147] ; National Natural Science Foundation of China[91743106] ; Youth Innovation Promotion Association of CAS[2020444] ; Anhui Provincial Key Research and Development Programs[202004i07020015] ; Hefei Institute of Physical Science[YZJJZX202014] ; Opening Foundation of Anhui Province of Key Laboratory of Environmental Toxicology and Pollution Control Technology[Y79AH72588] |
| WOS研究方向 | Engineering ; Environmental Sciences & Ecology |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000647609400005 |
| 资助机构 | National Natural Science Foundation of China ; Youth Innovation Promotion Association of CAS ; Anhui Provincial Key Research and Development Programs ; Hefei Institute of Physical Science ; Opening Foundation of Anhui Province of Key Laboratory of Environmental Toxicology and Pollution Control Technology |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/122270]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Xu, An; Liu, Yun |
| 作者单位 | 1.Anhui Univ, Inst Informat Technol, Hefei 230601, Anhui, Peoples R China 2.Chinese Acad Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Anhui, Peoples R China 3.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Anhui Prov Key Lab Environm Toxicol & Pollut Cont, Hefei 230031, Anhui, Peoples R China 4.Anhui Univ, Inst Phys Sci, Hefei 230601, Anhui, Peoples R China 5.Columbia Univ, Coll Phys & Surg, Ctr Radiol Res, Dept Radiat Oncol, New York, NY 10032 USA 6.Univ Sci & Technol China, Sch Environm Sci & Optoelect Technol, Hefei 230026, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xue,Nie, Yaguang,Si, Bo,et al. Silver nanoparticles protect against arsenic induced genotoxicity via attenuating arsenic bioaccumulation and elevating antioxidation in mammalian cells[J]. JOURNAL OF HAZARDOUS MATERIALS,2021,413. |
| APA | Wang, Xue.,Nie, Yaguang.,Si, Bo.,Wang, Tong.,Hei, Tom K..,...&Liu, Yun.(2021).Silver nanoparticles protect against arsenic induced genotoxicity via attenuating arsenic bioaccumulation and elevating antioxidation in mammalian cells.JOURNAL OF HAZARDOUS MATERIALS,413. |
| MLA | Wang, Xue,et al."Silver nanoparticles protect against arsenic induced genotoxicity via attenuating arsenic bioaccumulation and elevating antioxidation in mammalian cells".JOURNAL OF HAZARDOUS MATERIALS 413(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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