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Development of a non-invasive method for skin cholesterol detection: pre-clinical assessment in atherosclerosis screening

文献类型：期刊论文

作者Ni,Jingshu2,3; Hong,Haiou5; Zhang,Yang2,3; Tang,Shiqi6; Han,Yongsheng1; Fang,Zhaohui7; Zhang,Yuanzhi2,4; Zhou,Nan2,4; Wang,Quanfu2,4; Liu,Yong2,3,4
刊名BioMedical Engineering OnLine
出版日期2021-06-01
卷号20
关键词Non-invasive Skin cholesterol Absorption spectroscopy Subclinical atherosclerosis
DOI10.1186/s12938-021-00889-1
通讯作者Wang,YiKun(wyk@aiofm.ac.cn) ; Dong,Meili(dongmeili@aiofm.ac.cn)
英文摘要AbstractBackgroundEstablishing a high-accuracy and non-invasive method is essential for evaluating cardiovascular disease. Skin cholesterol is a novel marker for assessing the risk of atherosclerosis and can be used as an independent risk factor of early assessment of atherosclerotic risk.MethodsWe propose a non-invasive skin cholesterol detection method based on absorption spectroscopy. Detection reagents specifically bind to skin cholesterol and react with indicator to produce colored products, the skin cholesterol content can be obtained through absorption spectrum information on colored products detected by non-invasive technology. Gas chromatography is used to measure cholesterol extracted from the skin to verify the accuracy and reliability of the non-invasive test method. A total of 342 subjects were divided into normal group (n?=?115), disease group (n?=?110) and risk group (n?=?117). All subjects underwent non-invasive skin cholesterol test. The diagnostic accuracy of the measured value was analyzed by receiver-operating characteristic (ROC) curve.ResultsThe proposed method is able to identify porcine skin containing gradient concentration of cholesterol. The values measured by non-invasive detection method were significantly correlated with gas chromatography measured results (r?=?0.9074, n?=?73, p?
WOS关键词CARDIOVASCULAR RISK ; TISSUE CHOLESTEROL ; PRIMARY PREVENTION ; BARRIER FUNCTION ; STRATUM-CORNEUM ; DERMATITIS ; INFLAMMATION ; ABSORPTION ; DEPOSITION ; DIGITONIN
资助项目Science and Technology Major Project of Anhui Province of China[201903a07020027] ; Science and Technology Major Project of Anhui Province of China[17030801007] ; Science and Technology Major Project of Anhui Province of China[17030901017] ; Science and Technology Service Network Project, Chinese Academy of Sciences[KFJSTS-QYZD-184] ; Science and Technology Service Network Project, Chinese Academy of Sciences[KFF-STS-ZDTP-063] ; External Cooperation Program of the Bureau of International Cooperation, Chinese Academy of Sciences[116134KYSB20170018] ; Natural Science Foundation of Anhui Province of China[1908085QH365] ; Key research and Development Program of Anhui Province of China[1804b06020350] ; Key research and Development Program of Anhui Province of China[1804h08020291] ; Key research and Development Program of Anhui Province of China[202004a07020016]
WOS研究方向Engineering
语种英语
WOS记录号BMC:10.1186/S12938-021-00889-1
出版者BioMed Central
资助机构Science and Technology Major Project of Anhui Province of China ; Science and Technology Service Network Project, Chinese Academy of Sciences ; External Cooperation Program of the Bureau of International Cooperation, Chinese Academy of Sciences ; Natural Science Foundation of Anhui Province of China ; Key research and Development Program of Anhui Province of China
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/122289]  
专题中国科学院合肥物质科学研究院
通讯作者Wang,YiKun; Dong,Meili
作者单位1.First Affiliated Hospital of University of Science and Technology of China; Department of Cardiovascular Medicine
2.Chinese Academy of Sciences; Anhui Provincial Engineering Technology Research Center for Biomedical Optical Instrument, Anhui Institute of Optics and Fine Mechanics, Hefei Institutes of Physical Science
3.University of Science and Technology of China
4.Wanjiang Center for Development of Emerging Industrial Technology
5.First Affiliated Hospital of University of Science and Technology of China; Health Management Center
6.Renmin Hospital of WuHan University; Health Management Center
7.The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine; Department of Endocrinology
推荐引用方式
GB/T 7714		 Ni,Jingshu,Hong,Haiou,Zhang,Yang,et al. Development of a non-invasive method for skin cholesterol detection: pre-clinical assessment in atherosclerosis screening[J]. BioMedical Engineering OnLine,2021,20.
APA Ni,Jingshu.,Hong,Haiou.,Zhang,Yang.,Tang,Shiqi.,Han,Yongsheng.,...&Dong,Meili.(2021).Development of a non-invasive method for skin cholesterol detection: pre-clinical assessment in atherosclerosis screening.BioMedical Engineering OnLine,20.
MLA Ni,Jingshu,et al."Development of a non-invasive method for skin cholesterol detection: pre-clinical assessment in atherosclerosis screening".BioMedical Engineering OnLine 20(2021).

入库方式： OAI收割

来源：合肥物质科学研究院

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