Exploring the concepts and practices of advanced breast cancer treatment: a narrative review
文献类型:期刊论文
作者 | Wang, Xiaojia1,2; Shao, Xiying1,2; Huang, Jian1,2; Lei, Lei1,2; Huang, Yuan1,2; Zheng, Yabing1,2; Cao, Wenming1,2; Chen, Zhanhong1,2 |
刊名 | ANNALS OF TRANSLATIONAL MEDICINE |
出版日期 | 2021-04-01 |
卷号 | 9 |
ISSN号 | 2305-5839 |
关键词 | Metastatic breast cancer (MBC) treatment cure molecular types targeted therapy |
DOI | 10.21037/atm-21-1458 |
通讯作者 | Chen, Zhanhong(czred@sina.com) |
英文摘要 | Objective: To explore the concepts and practices of advanced breast cancer treatment. Background: Metastatic breast cancer (MBC) has become a chronic disease, with a median overall survival (OS) of around 3 years and a 5-year survival rate of about 25%. OS are strongly associated with the best available care, which consists of not only application of guidelines, but also multidisciplinary specialized care, the most efficacious medicines, and so on. Advanced breast cancer (ABC) Guidelines are the most important and authoritative guidelines for MBC. Methods: In this review, we demonstrate the history and evolution of the global ABC Guidelines. Since 2015, Chinese multidisciplinary experts have drafted guidelines for clinical diagnosis and treatment of MBC. All of these ABC guidelines describe specialized therapeutic principles for different subtypes MBC in detail. Encouragingly, we have found that some special subtypes are hopeful of being cured, such as HER2 positive patients with low tumor burden or HR-positive (HR+) MBC with non-visceral metastasis. In our opinion, the definition of cure of MBC is that MBC patients achieve CR and remain for more than five years after systemic treatment, including those with local therapy. Consequently, we also have conducted some researches and meaningful explorations in different subtypes of MBC. In HER2 positive MBC, our study revealed that regular HER2 circulating extracellular domain (ECD) assay can provide the real-time monitoring of tumor burden and prediction of poor outcome, and may present an important opportunity to reassess HER2 status. In HR+ MBC, we suggested that hormone therapy (HT) maintenance is the priority choice for HR+/HER2- MBC after first-line combined chemotherapy. Besides, our real-world study revealed that fulvestrant combined with ovarian suppression was an active option for premenopausal HR+/HER2- MBC. And also, we observed that everolimus (low-dose) combined with hormone therapy was still effective for HR+/HER2- MBC. For mTNBC patients, we found that THA and endostatin exhibited potential efficacy and was well tolerated in pretreated patients. Conclusions: Our concepts and practices will contribute to the design of relevant clinical research and accumulation of evidence, and cure of MBC is promising. |
WOS关键词 | INTERNATIONAL CONSENSUS GUIDELINES ; CHEMOTHERAPY ; CAPECITABINE ; FULVESTRANT ; COMBINATION ; MULTICENTER ; THERAPY ; WOMEN |
资助项目 | Key Project of Science and Technology Program of Zhejiang Province[2012C13019-1] ; Natural Science Foundation[81672597] ; Zhejiang Provincial Natural Science Foundation[Y2101312] ; Zhejiang Provincial Natural Science Foundation[LY17H160041] ; Zhejiang Provincial Medical Science and Technology Program[2021KY551] |
WOS研究方向 | Oncology ; Research & Experimental Medicine |
语种 | 英语 |
出版者 | AME PUBL CO |
WOS记录号 | WOS:000647719800007 |
资助机构 | Key Project of Science and Technology Program of Zhejiang Province ; Natural Science Foundation ; Zhejiang Provincial Natural Science Foundation ; Zhejiang Provincial Medical Science and Technology Program |
源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/122420] |
专题 | 中国科学院合肥物质科学研究院 |
通讯作者 | Chen, Zhanhong |
作者单位 | 1.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Med Oncol Breast Canc, Hangzhou, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Xiaojia,Shao, Xiying,Huang, Jian,et al. Exploring the concepts and practices of advanced breast cancer treatment: a narrative review[J]. ANNALS OF TRANSLATIONAL MEDICINE,2021,9. |
APA | Wang, Xiaojia.,Shao, Xiying.,Huang, Jian.,Lei, Lei.,Huang, Yuan.,...&Chen, Zhanhong.(2021).Exploring the concepts and practices of advanced breast cancer treatment: a narrative review.ANNALS OF TRANSLATIONAL MEDICINE,9. |
MLA | Wang, Xiaojia,et al."Exploring the concepts and practices of advanced breast cancer treatment: a narrative review".ANNALS OF TRANSLATIONAL MEDICINE 9(2021). |
入库方式: OAI收割
来源:合肥物质科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。