Real-time tracking of lipid droplets interactions with other organelles by a high signal/noise probe
文献类型：期刊论文
| 作者 | Ren, Wei2,3; Wang, Dong2,3; Huang, Wei2,3 ; Li, Jiajia2,3; Tian, Xiaohe2,3; Liu, Zhengjie2,3; Han, Guangmei2,3; Liu, Bianhua1; Han, Ming-Yong1; Zhang, Zhongping2,3,4
|
| 刊名 | DYES AND PIGMENTS
 |
| 出版日期 | 2021-07-01 |
| 卷号 | 191 |
| ISSN号 | 0143-7208 |
| 关键词 | Hydrophobic probe High signal/noise Lipid droplets Organelles interaction |
| DOI | 10.1016/j.dyepig.2021.109366 |
| 通讯作者 | Zhang, Ruilong(zrl@ahu.edu.cn) |
| 英文摘要 | Investigating the interactions between lipid droplets (LDs) and other organelles are greatly significant to the indepth understand the physiology and pathology of LDs. Despite of commercial LDs probes available, the ER and other membrane structures are also stained due to their amphiphilicity, which limits their further applications. To address this issue, we herein report a highly hydrophobic fluorescent probe to specifically label intracellular LDs with high signal/noise ratio, avoiding undesirable staining of ER and thus achieving to real-time monitor the interactions between LDs and other organelles. The probe showed strong emission in lipid environments but no fluorescence in water and liposomes, enabling the probe with high signal/noise ratio. Using this probe, it was found that the contacts of LDs with ER and mitochondria clearly increased under the condition of starvation. |
| WOS关键词 | FLUORESCENT-PROBES ; METABOLISM ; RAB18 ; ER |
| 资助项目 | National Natural Science Foundation of China[21775001] ; National Natural Science Foundation of China[21874137] ; National Natural Science Foundation of China[21974001] ; National Natural Science Foundation of China[21976183] ; National Natural Science Foundation of China[22074001] ; Anhui Provincial Natural Science Foundation of China[1808085MB32] |
| WOS研究方向 | Chemistry ; Engineering ; Materials Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCI LTD |
| WOS记录号 | WOS:000652615400004 |
| 资助机构 | National Natural Science Foundation of China ; Anhui Provincial Natural Science Foundation of China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/122608]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Zhang, Ruilong |
| 作者单位 | 1.Chinese Acad Sci, Inst Solid State Phys, Key Lab Photovolta & Energy Conservat Mat, HFIPS, Hefei 230031, Peoples R China 2.Anhui Univ, Sch Chem & Chem Engn, Hefei 230601, Peoples R China 3.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Peoples R China 4.Anhui Univ, Minist Educ, Key Lab Struct & Funct Regulat Hybrid Mat, Hefei 230601, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ren, Wei,Wang, Dong,Huang, Wei,et al. Real-time tracking of lipid droplets interactions with other organelles by a high signal/noise probe[J]. DYES AND PIGMENTS,2021,191. |
| APA | Ren, Wei.,Wang, Dong.,Huang, Wei.,Li, Jiajia.,Tian, Xiaohe.,...&Zhang, Ruilong.(2021).Real-time tracking of lipid droplets interactions with other organelles by a high signal/noise probe.DYES AND PIGMENTS,191. |
| MLA | Ren, Wei,et al."Real-time tracking of lipid droplets interactions with other organelles by a high signal/noise probe".DYES AND PIGMENTS 191(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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