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Association of advanced glycation end products with diabetic retinopathy in type 2 diabetes mellitus

文献类型：期刊论文

作者Ying, Lingwen2,3; Shen, Yun2,3; Zhang, Yang1,4; Wang, Yikun1; Liu, Yong1; Yin, Jun2,3; Wang, Yufei2,3; Yin, Jingrong2,3; Zhu, Wei2,3; Bao, Yuqian2,3
刊名DIABETES RESEARCH AND CLINICAL PRACTICE
出版日期2021-07-01
卷号177
关键词Diabetic retinopathy Advanced glycation end products Non-invasive Type 2 diabetes
ISSN号0168-8227
DOI10.1016/j.diabres.2021.108880
通讯作者Wang, Yikun(wyk@aiofm.ac.cn) ; Zhou, Jian(zhoujian@sjtu.edu.cn)
英文摘要Aims: Advanced glycation end products (AGEs) were reported to be associated with diabetes development and diabetes related complications when accumulated in high levels. This study investigated the association between AGEs and diabetic retinopathy (DR). Methods: A total of 1,471 patients with type 2 diabetes were enrolled. Fundus radiography was used for DR measurement. AGEs were detected through non-invasive skin autofluorescence method. Results: Patients with more advanced DR showed a much higher AGEs, and the prevalence of DR (based on the severity) increase with ascending AGEs quartiles (all P for trend < 0.001). The multivariable-adjusted odds ratios of any DR across AGEs quartiles were 1.00, 1.69 (95% confidence interval [CI] 1.16-2.47), 1.58 (95%CI 1.06-2.37) and 1.60 (95%CI 1.05-2.44) (P for trend = 0.044), respectively. Similar results were found in vision-threatening DR (VTDR) subgroup (P for trend = 0.009). When AGEs was considered as a continuous variable by using restricted cubic splines, a graded positive association of AGEs with the odds of any presence of DR was observed (P for trend < 0.001). Further, we found that AGEs presented the similar predictive value for any DR with glycated hemoglobin A(1c) (HbA(1c)). When it comes to VTDR, AGEs showed a significantly higher efficacy in early screening than HbA(1c) (P = 0.002). With a cut-off point of 77.1, the sensitivity, specificity and area under the curve of AGEs were 90.0% (95%CI 76.3-97.2%), 49.4% (95%CI 46.8-52.0%), and 0.728 (95%CI 0.704-0.750), respectively. Conclusion: Non-invasive measured skin AGEs, associated with the prevalence of all stages of DR, might be a more suitable indicator than HbA(1c) for mimicking the poor prognosis of hyperglycemia. (C) 2021 Elsevier B.V. All rights reserved.
WOS关键词SKIN AUTOFLUORESCENCE
资助项目National Key R&D Program of China[2018YFC2000802] ; Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support[20161430] ; Bureau of International Cooperation, Chinese Academy of Sciences[116134KYSB20170018] ; Key Research and Development Program of Anhui Province of China[1804b06020350]
WOS研究方向Endocrinology & Metabolism
语种英语
WOS记录号WOS:000680513200035
出版者ELSEVIER IRELAND LTD
资助机构National Key R&D Program of China ; Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support ; Bureau of International Cooperation, Chinese Academy of Sciences ; Key Research and Development Program of Anhui Province of China
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/123111]  
专题中国科学院合肥物质科学研究院
通讯作者Wang, Yikun; Zhou, Jian
作者单位1.Chinese Acad Sci, Anhui Inst Opt & Fine Mech, Hefei Inst Phys Sci, 350 Shushanhu Rd, Hefei 230031, Anhui, Peoples R China
2.Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Shanghai Clin Ctr Diabet, Dept Endocrinol & Metab, Shanghai 200233, Peoples R China
3.Shanghai Diabet Inst, Shanghai Key Lab Diabet Mellitus, Shanghai 200233, Peoples R China
4.Univ Sci & Technol China, Hefei 230026, Peoples R China
推荐引用方式
GB/T 7714		 Ying, Lingwen,Shen, Yun,Zhang, Yang,et al. Association of advanced glycation end products with diabetic retinopathy in type 2 diabetes mellitus[J]. DIABETES RESEARCH AND CLINICAL PRACTICE,2021,177.
APA Ying, Lingwen.,Shen, Yun.,Zhang, Yang.,Wang, Yikun.,Liu, Yong.,...&Zhou, Jian.(2021).Association of advanced glycation end products with diabetic retinopathy in type 2 diabetes mellitus.DIABETES RESEARCH AND CLINICAL PRACTICE,177.
MLA Ying, Lingwen,et al."Association of advanced glycation end products with diabetic retinopathy in type 2 diabetes mellitus".DIABETES RESEARCH AND CLINICAL PRACTICE 177(2021).

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来源：合肥物质科学研究院

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