An Effective Brain Imaging Biomarker for AD and aMCI: ALFF in Slow-5 Frequency Band
文献类型：期刊论文
| 作者 | Wang, Luoyu2,3,4,5; Feng, Qi2; Wang, Mei2; Zhu, Tingting3,4,5; Yu, Enyan7; Niu, Jialing2; Ge, Xiuhong2; Mao, Dewang1; Lv, Yating3,4,5; Ding, Zhongxiang2,6 |
| 刊名 | CURRENT ALZHEIMER RESEARCH
 |
| 出版日期 | 2021 |
| 卷号 | 18 |
| ISSN号 | 1567-2050 |
| 关键词 | Alzheimer's disease amnestic mild cognitive impairment resting-state functional magnetic resonance imaging amplitude of low frequency fluctuation slow-5 frequency band support vector machine |
| DOI | 10.2174/1567205018666210324130502 |
| 通讯作者 | Lv, Yating(lvyating198247@gmail.com) ; Ding, Zhongxiang(hangzhoudzx73@126.com) |
| 英文摘要 | Background: As a potential brain imaging biomarker, amplitude of low frequency fluctuation (ALFF) has been used as a feature to distinguish patients with Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) from normal controls (NC). However, it remains unclear whether the frequency-dependent pattern of ALFF alterations can effectively distinguish the different phases of the disease. Methods: In the present study, 52 AD and 50 aMCI patients were enrolled together with 43 NC in total. The ALFF values were calculated in the following three frequency bands: classical (0.01-0.08 Hz), slow-4 (0.027-0.073 Hz) and slow-5 (0.01-0.027 Hz) for the three different groups. Subsequently, the local functional abnormalities were employed as features to examine the effect of classification among AD, aMCI and NC using a support vector machine (SVM). Results: We found that the among-group differences of ALFF in the different frequency bands were mainly located in the left hippocampus (HP), right HP, bilateral posterior cingulate cortex (PCC) and bilateral precuneus (PCu), left angular gyrus (AG) and left medial prefrontal cortex (mPFC). When the local functional abnormalities were employed as features, we identified that the ALFF in the slow-5 frequency band showed the highest accuracy to distinguish among the three groups. Conclusion: These findings may deepen our understanding of the pathogenesis of AD and suggest that slow-5 frequency band may be helpful to explore the pathogenesis and distinguish the phases of this disease. |
| WOS关键词 | MILD COGNITIVE IMPAIRMENT ; RESTING-STATE FMRI ; ALZHEIMERS-DISEASE ; DEFAULT-MODE ; FUNCTIONAL CONNECTIVITY ; ANGULAR GYRUS ; ACTIVATION ; RETRIEVAL ; DIAGNOSIS ; NETWORKS |
| 资助项目 | National Key R&D Program of China[2017YFC1310000] ; National Natural Science Foundation of China[81871337] ; National Natural Science Foundation of China[81771158] ; National Natural Science Foundation of China[81771911] ; National Natural Science Foundation of China[81301210] ; Science Foundation from Health Commission of Zhejiang Province[2020369796] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| WOS记录号 | WOS:000674322400006 |
| 资助机构 | National Key R&D Program of China ; National Natural Science Foundation of China ; Science Foundation from Health Commission of Zhejiang Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/123260]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Lv, Yating; Ding, Zhongxiang |
| 作者单位 | 1.Zhejiang Prov Peoples Hosp, Hangzhou Med Coll, Dept Radiol, Hangzhou, Zhejiang, Peoples R China 2.Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Radiol, Sch Med, 261 Huansha Rd, Hangzhou 310006, Zhejiang, Peoples R China 3.Zhejiang Key Lab Res Assessment Cognit Impairment, Hangzhou, Zhejiang, Peoples R China 4.Hangzhou Normal Univ, Affiliated Hosp, Ctr Cognit & Brain Disorders, Hangzhou, Zhejiang, Peoples R China 5.Hangzhou Normal Univ, Inst Psychol Sci, 2318 Yuhangtang Rd, Hangzhou 311121, Zhejiang, Peoples R China 6.Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Key Lab Clin Canc Pharmacol & Toxicol Res Zhejian, Sch Med,Translat Med Res Ctr, Hangzhou, Peoples R China 7.Univ Chinese Acad Sci, Canc Hosp, Hangzhou, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Luoyu,Feng, Qi,Wang, Mei,et al. An Effective Brain Imaging Biomarker for AD and aMCI: ALFF in Slow-5 Frequency Band[J]. CURRENT ALZHEIMER RESEARCH,2021,18. |
| APA | Wang, Luoyu.,Feng, Qi.,Wang, Mei.,Zhu, Tingting.,Yu, Enyan.,...&Ding, Zhongxiang.(2021).An Effective Brain Imaging Biomarker for AD and aMCI: ALFF in Slow-5 Frequency Band.CURRENT ALZHEIMER RESEARCH,18. |
| MLA | Wang, Luoyu,et al."An Effective Brain Imaging Biomarker for AD and aMCI: ALFF in Slow-5 Frequency Band".CURRENT ALZHEIMER RESEARCH 18(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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