Application of Multigroup Technology in Non-Small-Cell Lung Cancer with Qi Stagnation and Blood Stasis Syndrome
文献类型：期刊论文
| 作者 | Ma, Guan-Jun1; Qian, Xiang3,4; Chen, Zhuo3,4; Chen, Sha-Sha2; Zhang, Ai-Qin3,4 |
| 刊名 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
 |
| 出版日期 | 2021-07-09 |
| 卷号 | 2021 |
| ISSN号 | 1741-427X |
| DOI | 10.1155/2021/6522191 |
| 通讯作者 | Zhang, Ai-Qin(zhanghaojianbb@163.com) |
| 英文摘要 | Objective. To explore the basic characteristics of intestinal flora, metabolomics, and proteomics of non-small cell lung cancer (NSCLC) in patients with Qi stagnation and blood stasis syndrome. Methods. Twelve NSCLC patients with Qi stagnation and blood stasis syndrome were selected for the QZXY group and 15 healthy volunteers were selected for the control group. Fecal samples from the two groups were collected to evaluate intestinal microecology using the 16s rDNA technique. Serum samples were collected to compare the differences in metabolomics and proteomics between the two groups using liquid chromatography-mass spectrometry (LC-MS). Another 34 NSCLC patients with other syndromes were selected for the nQZXY group and their serum samples were collected. Metabolomics differences between the QZXY and nQZXY groups were compared using LC-MS, and four metabolites with the most obvious differences were selected for receiver operation characteristic curve representation. Finally, multigroup results were analyzed using the WGCNA software. Results. There were two significantly different types of bacteria (Aerococcaceae and Abiotrophia), 11 different proteins (six upregulated and five downregulated), and 38 different metabolites (nine upregulated, 29 downregulated) between the QZXY and control groups. There was a correlation between differential bacteria, proteins, and metabolites. The conjoint analysis found that the different substances were related to MAPK, PI3K/Akt, Ras signaling pathway, cancer pathways, and cytokine-cytokine receptor interaction. There were four significant differences in metabolites (Pseudouridine, phenlacetyl-C0A, L-glutamic, and phospho-anandamide) between the QZXY and nQZXY groups. Conclusions. NSCLC with Qi stagnation and blood stasis syndrome had specific intestinal flora and protein and metabolites, which were closely related to the occurrence and development of tumors. |
| 资助项目 | National Natural Science Foundation of China, Study on the Immune Regulation Effect of Intestinal Akk Bacteria in Lung Cancer Mice and the Intervention of Qingfei Mixture Based on the Theory of Lung and Large Intestine Surface and Inside[81973771] ; Zhejiang Provincial Traditional Chinese Medicine Science and Technology Plan Project: Study on the Correlation between TCM Syndromes and Modern Biomarkers in Patients with Non-Small Cell Lung Cancer Based on Intestinal Microflora Structure Characteristics[2019ZZ002] ; Affilliation: Institute of Basic Medicine and Cancer, Chinese Academy of Sciences, Hangzhou, China. |
| WOS研究方向 | Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000675812300004 |
| 出版者 | HINDAWI LTD |
| 资助机构 | National Natural Science Foundation of China, Study on the Immune Regulation Effect of Intestinal Akk Bacteria in Lung Cancer Mice and the Intervention of Qingfei Mixture Based on the Theory of Lung and Large Intestine Surface and Inside ; Zhejiang Provincial Traditional Chinese Medicine Science and Technology Plan Project: Study on the Correlation between TCM Syndromes and Modern Biomarkers in Patients with Non-Small Cell Lung Cancer Based on Intestinal Microflora Structure Characteristics ; Affilliation: Institute of Basic Medicine and Cancer, Chinese Academy of Sciences, Hangzhou, China. |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/123284]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Zhang, Ai-Qin |
| 作者单位 | 1.Zhejiang Univ, Affiliated Hangzhou Canc Hosp, Dept Geriatr Oncol, Sch Med, 34 Yanguan Lane, Hangzhou 310002, Peoples R China 2.Taizhou Canc Hosp, Dept Tradit Chinese Med, 50 Zhenxin Rd, Wenling 317502, Zhejiang, Peoples R China 3.Chinese Acad Sci, Inst Basic Med & Canc IBMC, 1 Banshandong Rd, Hangzhou 310022, Zhejiang, Peoples R China 4.Zhejiang Canc Hosp, Dept Tradit Chinese Med, Canc Hosp, Univ Chinese Acad Sci, 1 Banshandong Rd, Hangzhou 310022, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Guan-Jun,Qian, Xiang,Chen, Zhuo,et al. Application of Multigroup Technology in Non-Small-Cell Lung Cancer with Qi Stagnation and Blood Stasis Syndrome[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2021,2021. |
| APA | Ma, Guan-Jun,Qian, Xiang,Chen, Zhuo,Chen, Sha-Sha,&Zhang, Ai-Qin.(2021).Application of Multigroup Technology in Non-Small-Cell Lung Cancer with Qi Stagnation and Blood Stasis Syndrome.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2021. |
| MLA | Ma, Guan-Jun,et al."Application of Multigroup Technology in Non-Small-Cell Lung Cancer with Qi Stagnation and Blood Stasis Syndrome".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2021(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。