Connexin26 Modulates the Radiosensitivity of Cutaneous Squamous Cell Carcinoma by Regulating the Activation of the MAPK/NF-kappa B Signaling Pathway
文献类型：期刊论文
| 作者 | Sun, Minqiong2; Li, Yuan2; Qian, Jing2 ; Ding, Siwei2; Sun, Mingyu1,2; Tan, Bowen2; Zhao, Ye2
|
| 刊名 | FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
 |
| 出版日期 | 2021-07-05 |
| 卷号 | 9 |
| 关键词 | Connexin 26 cutaneous squamous cell carcinoma radiosensitivity MAPK/NF-kappa B signaling pathway radiotherapy |
| ISSN号 | 2296-634X |
| DOI | 10.3389/fcell.2021.672571 |
| 通讯作者 | Zhao, Ye(zhaoye@ahmu.edu.cn) |
| 英文摘要 | Y Previous studies have confirmed that the gap junction protein Connexin26 (Cx26) is specifically expressed in human skin tissue. Cx26 can transmit radiation-induced damage signals. However, no study has yet reported whether Cx26 expression affects the radiosensitivity of human skin squamous cancer cells or the mechanism by which this occurs. In this study, we found that human skin squamous cell carcinoma cells (A431 cells) expressed significantly more Cx26 and were more sensitive to radiation compared to normal human keratinocytes (HaCaT cells). Knockdown of Cx26 in A431 cells (A431Cx26) decreased radiosensitivity relative to control cells and altered the expression of key proteins in the MAPK and NF-kappa B signaling pathways. These results demonstrate that Cx26 expression might play an important role in mediating radiation damage in A431 cells and could serve as a potential target for clinical radiotherapy for cutaneous squamous cell carcinoma. |
| WOS关键词 | JUNCTIONAL INTERCELLULAR COMMUNICATION ; PROTECT H2O2-INDUCED INHIBITION ; EXPRESSION ; KINASES |
| 资助项目 | National Natural Science Foundation of China[81673099] ; National Natural Science Foundation of China[31600680] ; National Natural Science Foundation of China[31670860] ; National Natural Science Foundation of China[31800702] ; State Key Laboratory of Nuclear Physics and Technology, Peking University[NPT2020KFY19] |
| WOS研究方向 | Cell Biology ; Developmental Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000674269400001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | National Natural Science Foundation of China ; State Key Laboratory of Nuclear Physics and Technology, Peking University |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/123311]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Zhao, Ye |
| 作者单位 | 1.Chinese Acad Sci, Hefei Inst Phys Sci, Ctr Med Phys & Technol, Hefei, Peoples R China 2.Anhui Med Univ, Sch Basic Med Sci, Teaching & Res Sect Nucl Med, Hefei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Minqiong,Li, Yuan,Qian, Jing,et al. Connexin26 Modulates the Radiosensitivity of Cutaneous Squamous Cell Carcinoma by Regulating the Activation of the MAPK/NF-kappa B Signaling Pathway[J]. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,2021,9. |
| APA | Sun, Minqiong.,Li, Yuan.,Qian, Jing.,Ding, Siwei.,Sun, Mingyu.,...&Zhao, Ye.(2021).Connexin26 Modulates the Radiosensitivity of Cutaneous Squamous Cell Carcinoma by Regulating the Activation of the MAPK/NF-kappa B Signaling Pathway.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,9. |
| MLA | Sun, Minqiong,et al."Connexin26 Modulates the Radiosensitivity of Cutaneous Squamous Cell Carcinoma by Regulating the Activation of the MAPK/NF-kappa B Signaling Pathway".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 9(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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