中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 合肥物质科学研究院
  3. 中国科学院合肥物质科学研究院
Magnetic sensitivity of cryptochrome 4 from a migratory songbird

文献类型：期刊论文

作者Xu, Jingjing6; Jarocha, Lauren E.7; Zollitsch, Tilo7; Konowalczyk, Marcin8; Henbest, Kevin B.7,8; Richert, Sabine10; Golesworthy, Matthew J.8; Schmidt, Jessica6; Dejean, Victoire8; Sowood, Daniel J. C.7
刊名NATURE
出版日期2021-06-24
卷号594
ISSN号0028-0836
DOI10.1038/s41586-021-03618-9
通讯作者Solov'yov, Ilia A.(ilia.solovyov@uni-oldenburg.de) ; Xie, Can(canxie@hmfl.ac.cn) ; Mackenzie, Stuart R.(stuart.mackenzie@chem.ox.ac.uk) ; Timmel, Christiane R.(christiane.timmel@chem.ox.ac.uk) ; Mouritsen, Henrik(henrik.mouritsen@uni-oldenburg.de) ; Hore, P. J.(peter.hore@chem.ox.ac.uk)
英文摘要Night-migratory songbirds are remarkably proficient navigators(1). Flying alone and often over great distances, they use various directional cues including, crucially, a light-dependent magnetic compass(2,3). The mechanism of this compass has been suggested to rely on the quantum spin dynamics of photoinduced radical pairs in cryptochrome flavoproteins located in the retinas of the birds(4-7). Here we show that the photochemistry of cryptochrome 4 (CRY4) from the night-migratory European robin (Erithacus rubecula) is magnetically sensitive in vitro, and more so than CRY4 from two non-migratory bird species, chicken (Gallus gallus) and pigeon (Columba livia). Site-specific mutations of ErCRY4 reveal the roles of four successive flavin-tryptophan radical pairs in generating magnetic field effects and in stabilizing potential signalling states in a way that could enable sensing and signalling functions to be independently optimized in night-migratory birds.
WOS关键词RADICAL-PAIR MECHANISM ; ANIMAL CRYPTOCHROMES ; ELECTRON-TRANSFER ; MAGNETORECEPTION ; FIELDS ; MODEL ; ORIENTATION ; CONSISTENT
资助项目Air Force Office of Scientific Research (Air Force Materiel Command, USAF)[FA9550-14-1-0095] ; European Research Council (European Union)[810002] ; Office of Naval Research Global[N62909-19-1-2045] ; Deutsche Forschungsgemeinschaft[SFB 1372] ; Deutsche Forschungsgemeinschaft[395940726] ; Deutsche Forschungsgemeinschaft[GRK 1885] ; DAAD (German Academic Exchange Service, Graduate School Scholarship Programme)[57395813] ; SCG Innovation Fund ; Electromagnetic Fields Biological Research Trust ; National Natural Science Foundation of China[31640001] ; Presidential Foundation of Hefei Institutes of Physical Science, Chinese Academy of Sciences[BJZX201901] ; Lundbeck Foundation ; Danish Councils for Independent Research ; Volkswagen Foundation ; Biotechnology and Biological Sciences Research Council[BB/M011224/1] ; Clarendon Fund ; CAESR, Engineering and Physical Sciences Research Council[EP/L011972/1] ; Clarendon Fund, University of Oxford
WOS研究方向Science & Technology - Other Topics
语种英语
出版者NATURE RESEARCH
WOS记录号WOS:000665247800015
资助机构Air Force Office of Scientific Research (Air Force Materiel Command, USAF) ; European Research Council (European Union) ; Office of Naval Research Global ; Deutsche Forschungsgemeinschaft ; DAAD (German Academic Exchange Service, Graduate School Scholarship Programme) ; SCG Innovation Fund ; Electromagnetic Fields Biological Research Trust ; National Natural Science Foundation of China ; Presidential Foundation of Hefei Institutes of Physical Science, Chinese Academy of Sciences ; Lundbeck Foundation ; Danish Councils for Independent Research ; Volkswagen Foundation ; Biotechnology and Biological Sciences Research Council ; Clarendon Fund ; CAESR, Engineering and Physical Sciences Research Council ; Clarendon Fund, University of Oxford
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/123385]  
专题中国科学院合肥物质科学研究院
通讯作者Solov'yov, Ilia A.; Xie, Can; Mackenzie, Stuart R.; Timmel, Christiane R.; Mouritsen, Henrik; Hore, P. J.
作者单位1.Carl von Ossietzky Univ Oldenburg, Dept Phys, Oldenburg, Germany
2.Carl von Ossietzky Univ Oldenburg, Res Ctr Neurosensory Sci, Oldenburg, Germany
3.Univ Texas Southwestern Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX 75390 USA
4.Univ Texas Southwestern Med Ctr Dallas, Dept Neurosci, Dallas, TX 75390 USA
5.Carl von Ossietzky Univ Oldenburg, Dept Neurosci, Div Biochem, Oldenburg, Germany
6.Carl von Ossietzky Univ Oldenburg, Inst Biol & Umweltwissensch, AG Neurosensory Sci Anim Nav, Oldenburg, Germany
7.Univ Oxford, Dept Chem, Phys & Theoret Chem Lab, Oxford, England
8.Univ Oxford, Dept Chem, Inorgan Chem Lab, Oxford, England
9.Purdue Univ, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA
10.Albert Ludwigs Univ Freiburg, Inst Phys Chem, Freiburg, Germany
推荐引用方式
GB/T 7714		 Xu, Jingjing,Jarocha, Lauren E.,Zollitsch, Tilo,et al. Magnetic sensitivity of cryptochrome 4 from a migratory songbird[J]. NATURE,2021,594.
APA Xu, Jingjing.,Jarocha, Lauren E..,Zollitsch, Tilo.,Konowalczyk, Marcin.,Henbest, Kevin B..,...&Hore, P. J..(2021).Magnetic sensitivity of cryptochrome 4 from a migratory songbird.NATURE,594.
MLA Xu, Jingjing,et al."Magnetic sensitivity of cryptochrome 4 from a migratory songbird".NATURE 594(2021).

入库方式： OAI收割

来源：合肥物质科学研究院

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。