An upward 9.4 T static magnetic field inhibits DNA synthesis and increases ROS-P53 to suppress lung cancer growth
文献类型：期刊论文
| 作者 | Yang, Xingxing4,5; Song, Chao4,5; Zhang, Lei5 ; Wang, Junjun3,5; Yu, Xin4,5; Yu, Biao4,5; Zablotskii, Vitalii1,2; Zhang, Xin1,3,4,5
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| 刊名 | TRANSLATIONAL ONCOLOGY
 |
| 出版日期 | 2021-07-01 |
| 卷号 | 14 |
| 关键词 | 9 4 T static magnetic field (SMF) Lung cancer Cell cycle P53 ROS |
| ISSN号 | 1936-5233 |
| DOI | 10.1016/j.tranon.2021.101103 |
| 通讯作者 | Zhang, Xin(xinzhang@hmfl.ac.cn) |
| 英文摘要 | Studies have shown that 9.4 Tesla (9.4 T) high-field magnetic resonance imaging (MRI) has obvious advantages in improving image resolution and capacity, but their safety issues need to be further validated before their clinical approval. Meanwhile, emerging experimental evidences show that moderate to high intensity Static Magnetic Fields (SMFs) have some anti-cancer effects. We examined the effects of two opposite SMF directions on lung cancer bearing mice and found when the lung cancer cell-bearing mice were treated with 9.4 T SMFs for 88 h in total, the upward 9.4 T SMF significantly inhibited A549 tumor growth (tumor growth inhibition = 41%), but not the downward 9.4 T SMF. In vitro cellular analysis shows that 9.4 T upward SMF treatment for 24 h not only inhibited A549 DNA synthesis, but also significantly increased ROS and P53 levels, and arrested G2 cell cycle. Moreover, the 9.4 T SMF-treatments for 88 h had no severe impairment to the key organs or blood cell count of the mice. Our findings demonstrated the safety of 9.4 T SMF long-term exposure for their future applications in MRI, and revealed the anti-cancer potential of the upward direction 9.4 T SMF. |
| WOS关键词 | HUMAN BRAIN ; P53 ; CELLS ; REPLICATION ; ORIENTATION ; EXPOSURE ; PATHWAY ; MRI |
| 资助项目 | National Key R&D Program of China[2016YFA0400900] ; National Natural Science Foundation of China[31900506] ; CASHIPS Director's Fund[YZJJ201704] ; CASHIPS Director's Fund[KP-2017-26] ; Heye Health Technology Foundation[HYJJ20190801] ; National Science Foundation for Young Scientists of China[31900506] ; National Science Foundation of Anhui Province[1908085MA11] ; China Postdoctoral Science Foundation[2019M652222] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000663384600009 |
| 出版者 | ELSEVIER SCIENCE INC |
| 资助机构 | National Key R&D Program of China ; National Natural Science Foundation of China ; CASHIPS Director's Fund ; Heye Health Technology Foundation ; National Science Foundation for Young Scientists of China ; National Science Foundation of Anhui Province ; China Postdoctoral Science Foundation |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/123944]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Zhang, Xin |
| 作者单位 | 1.Int Magnetobiol Frontier Res Ctr iMFRC, Sci Isl, Prague 230031, Czech Republic 2.Czech Acad Sci, Inst Phys, Prague 18221, Czech Republic 3.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Peoples R China 4.Univ Sci & Technol China, Sci Isl Branch, Grad Sch, Hefei 230026, Anhui, Peoples R China 5.Chinese Acad Sci, Hefei Inst Phys Sci, CAS Key Lab High Magnet Field & Ion Beam Phys Bio, High Field Magnet Lab, Hefei 230031, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Xingxing,Song, Chao,Zhang, Lei,et al. An upward 9.4 T static magnetic field inhibits DNA synthesis and increases ROS-P53 to suppress lung cancer growth[J]. TRANSLATIONAL ONCOLOGY,2021,14. |
| APA | Yang, Xingxing.,Song, Chao.,Zhang, Lei.,Wang, Junjun.,Yu, Xin.,...&Zhang, Xin.(2021).An upward 9.4 T static magnetic field inhibits DNA synthesis and increases ROS-P53 to suppress lung cancer growth.TRANSLATIONAL ONCOLOGY,14. |
| MLA | Yang, Xingxing,et al."An upward 9.4 T static magnetic field inhibits DNA synthesis and increases ROS-P53 to suppress lung cancer growth".TRANSLATIONAL ONCOLOGY 14(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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