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Pathological analysis and surgical modalities selection of cT1N0M0 solitary papillary thyroid carcinoma in the isthmus

文献类型：期刊论文

作者Zhang, Li-Zhuo1,2,3; Xu, Jia-Jie2,3; Ge, Xin-Yang4; Wang, Ke-Jing5; Tan, Zhuo2,3; Jin, Tie-Feng1,2,3; Zhang, Wan-Chen1,2,3; Li, Qing-Lin6; Luo, Ding-Cun7; Ge, Ming-Hua2,3
刊名GLAND SURGERY
出版日期2021-08-05
ISSN号2227-684X
关键词Papillary thyroid carcinoma (PTC) thyroid isthmus lymph node metastases
DOI10.21037/gs-21-357
通讯作者Li, Qing-Lin(qinglin200886@126.com) ; Luo, Ding-Cun(ldc65@163.com) ; Ge, Ming-Hua(gemingh@163.com)
英文摘要Background: prognosis, identify clinicopathological characteristics, and determine optimal modalities for cT1N0M0 solitary papillary thyroid carcinoma in the isthmus (PTCI). Methods: The clinical data of 124 patients with cT1N0M0 solitary PTCI from 3 medical centers were analyzed retrospectively. Of these, 32 participants had undergone total thyroidectomy plus unilateral central neck dissection, 36 had received total thyroidectomy plus bilateral central neck dissection, 24 had less-than-total thyroidectomy plus unilateral central neck dissection, and 32 had less-than-total thyroidectomy plus bilateral central neck dissection. We compared the effects of different surgical modalities and clinicopathological characteristics on the prognosis of cT1N0M0 solitary PTCI. Results: There was no significant difference in postoperative recurrence-free survival between participants who received different extents of central region lymph node dissection and thyroidectomies (P>0.05). Temporary hypocalcemia occurred in participants who underwent total thyroidectomy plus bilateral central neck dissection [chi-square (X2) =7.87, P=0.005]. Tumors with primary lesions >_0.55 cm were prone to have central lymph node metastasis [95% confidence interval (CI): 0.51 to 0.71, P=0.047]. Multiple logistic analysis suggested that age over 55 years [odds ration (OR) =11.90, 95% CI: 1.36 to 104.03, P=0.025], tumor size greater than 0.55 cm (OR =4.16, 95% CI: 1.28 to 13.52, P=0.018), and absence of nodular goiter (OR =2.57, 95% CI: 1.05 to 6.32, P=0.04) were risk factors for central lymph node metastasis of patients with cT1N0M0 solitary PTCI. Conclusions: Less-than-total thyroidectomy is recommended for patients with cT1N0M0 solitary PTCI. Central lymph node dissection is recommended for patients who are prone to have central occult lymph node metastases with tumor size >_55 cm, older than 55 years, and without nodular goiter.
WOS关键词LYMPH-NODE METASTASIS ; NECK DISSECTION ; ASSOCIATION GUIDELINES ; CARBON NANOPARTICLES ; RISK-FACTORS ; CANCER ; MICROCARCINOMA ; NODULES ; EXTENT ; STRATEGIES
资助项目Key Research and Development Program of Zhejiang Province[2021C0308] ; National Natural Science Foundation of China[81802674] ; Zhejiang Provincial Natural Science Foundation of China[LY21H160049] ; Medical and Health Research Program of Zhejiang Province[2021419088] ; Zhejiang TCM Excellence Young Talents Fund Project[2018ZQ010] ; National Natural Science Foundation of China-Zhejiang Joint Fund[U20A20382]
WOS研究方向Surgery
语种英语
出版者AME PUBL CO
WOS记录号WOS:000684961500001
资助机构Key Research and Development Program of Zhejiang Province ; National Natural Science Foundation of China ; Zhejiang Provincial Natural Science Foundation of China ; Medical and Health Research Program of Zhejiang Province ; Zhejiang TCM Excellence Young Talents Fund Project ; National Natural Science Foundation of China-Zhejiang Joint Fund
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/124263]  
专题中国科学院合肥物质科学研究院
通讯作者Li, Qing-Lin; Luo, Ding-Cun; Ge, Ming-Hua
作者单位1.Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou, Peoples R China
2.Hangzhou Med Coll, Dept Head & Neck Surg, Ctr Otolaryngol Head & Neck Surg, Zhejiang Prov Peoples Hosp,Peoples Hosp, 158 Shangtang Rd, Hangzhou 310014, Peoples R China
3.Hangzhou Med Coll, Peoples Hosp, Zhejiang Prov Peoples Hosp, Key Lab Endocrine Gland Dis Zhejiang Prov, Hangzhou, Peoples R China
4.Univ Calif Los Angeles, Coll Letters & Sci, Los Angeles, CA USA
5.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Head & Neck Surg, Hangzhou, Peoples R China
6.Univ Chinese Acad Sci, Canc Hosp, Dept Sci Res, 1 Banshan East Rd, Hangzhou 310022, Peoples R China
7.Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Surg Oncol, Sch Med, 261 Huansha Rd, Hangzhou 310006, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Li-Zhuo,Xu, Jia-Jie,Ge, Xin-Yang,et al. Pathological analysis and surgical modalities selection of cT1N0M0 solitary papillary thyroid carcinoma in the isthmus[J]. GLAND SURGERY,2021.
APA Zhang, Li-Zhuo.,Xu, Jia-Jie.,Ge, Xin-Yang.,Wang, Ke-Jing.,Tan, Zhuo.,...&Ge, Ming-Hua.(2021).Pathological analysis and surgical modalities selection of cT1N0M0 solitary papillary thyroid carcinoma in the isthmus.GLAND SURGERY.
MLA Zhang, Li-Zhuo,et al."Pathological analysis and surgical modalities selection of cT1N0M0 solitary papillary thyroid carcinoma in the isthmus".GLAND SURGERY (2021).

入库方式： OAI收割

来源：合肥物质科学研究院

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