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Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma

文献类型：期刊论文

作者Yang, Ke1,2; Wu, Ke1; Feng, Jianguo1; Yutian, Ling1; Zhu, Xin1,2; Xu, Dong1,2
刊名EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
出版日期2021-07-15
卷号2021
ISSN号1741-427X
DOI10.1155/2021/5526581
通讯作者Zhu, Xin(zhuxin@zjcc.org.cn) ; Xu, Dong(xudong@zjcc.org.cn)
英文摘要Objective. To investigate the antitumor effect of andrographolide on the ATC cell lines 8505C and CAL62 and to explore the possible mechanism of the effect. Methods. CCK8 and colony formation assays were performed to detect proliferation. Cell migration was tested by scratch assay. Annexin V/PI staining was used to detect cell apoptosis and cell cycle. Glucose and lactic acid kits were carried out to evaluate the glycolysis level after andrographolide treatment. Western blot was used to detect the changes in the apoptosis-related proteins and glycolysis-related enzymes in both 8505C and CAL62 cells. Results. Treatment with 60 mu M andrographolide had significant effects on 8505C and CAL62, including inhibition of proliferation, inhibition of migration, arrest of the cell cycle, promotion of apoptosis, and inhibition of glycolysis. Conclusion. Andrographolide has an antitumor effect and can significantly affect glycolysis in ATC cells.
WOS关键词APOPTOSIS ; INHIBITION ; ANTICANCER ; ACTIVATION
资助项目National Natural Science Foundation of China[82072950]
WOS研究方向Integrative & Complementary Medicine
语种英语
WOS记录号WOS:000680521900006
出版者HINDAWI LTD
资助机构National Natural Science Foundation of China
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/124338]  
专题中国科学院合肥物质科学研究院
通讯作者Zhu, Xin; Xu, Dong
作者单位1.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Zhejiang Canc Hosp, Canc Hosp,Univ Chinese Acad Sci, Hangzhou 310022, Zhejiang, Peoples R China
2.Key Lab Head & Neck Canc Translat Res Zhejiang Pr, Hangzhou 310022, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Ke,Wu, Ke,Feng, Jianguo,et al. Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2021,2021.
APA Yang, Ke,Wu, Ke,Feng, Jianguo,Yutian, Ling,Zhu, Xin,&Xu, Dong.(2021).Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2021.
MLA Yang, Ke,et al."Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2021(2021).

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来源：合肥物质科学研究院

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