Upconversion-based dual-mode optical nanosensor for highly sensitive and colorimetric evaluation of heparin in serum
文献类型：期刊论文
| 作者 | Zhu, Jiawei1,2; Hu, Bin1,2; Yang, Liang1,3; Jiang, Changlong1,3
|
| 刊名 | SENSORS AND ACTUATORS B-CHEMICAL
 |
| 出版日期 | 2021-10-15 |
| 卷号 | 345 |
| 关键词 | Upconversion-based nanosensor Dual-mode probe Visual quantitative sensing Smartphone-sensing platform Heparin |
| DOI | 10.1016/j.snb.2021.130378 |
| 通讯作者 | Yang, Liang(yangliang@iim.ac.cn) ; Jiang, Changlong(cljiang@iim.ac.cn) |
| 英文摘要 | Heparin is an important anticoagulant in clinics, which requires regular detection and dose adjustment. Fluo-rimetry is a powerful tool considering the advantages of fast response and high sensitivity while most fluorescent sensors suffer from spontaneous fluorescence for excitation under short-wavelength light, the occurrence of false positives, complex and time-consuming preparation, as well as expensive detection instruments. Herein, we developed upconversion nanoparticles (UCNPs) based nanosensor for fluorescent and colorimetric detection of heparin. The nanosensor exhibited sensitive detection for heparin with the low limit of detection (LOD) of 0.1 nM in fluorescent mode and 0.3 nM in colorimetric mode. In addition, we used a smartphone-sensing platform for quantitative detection of heparin with the LOD of 2 nM. Depending on long-wavelength excitation and fluorescent-colorimetric dual-response detection signal, the designed nanosensor could eliminate the auto-fluorescence, which effectively increased the accuracy of the sensor, thus extending the applications for bed -side heparin assay and related medical safety. |
| WOS关键词 | FLUORESCENCE SENSOR ; NANOPARTICLES ; CONTRAST ; PLATFORM |
| 资助项目 | National Natural Science Foundation of China[21671052] ; National Natural Science Foundation of China[21806168] ; Key Research and Development Program of Anhui Province[202004d07020013] ; Key Research and Development Program of Anhui Province[1804a07020103] |
| WOS研究方向 | Chemistry ; Electrochemistry ; Instruments & Instrumentation |
| 语种 | 英语 |
| WOS记录号 | WOS:000685514600005 |
| 出版者 | ELSEVIER SCIENCE SA |
| 资助机构 | National Natural Science Foundation of China ; Key Research and Development Program of Anhui Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/124410]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Yang, Liang; Jiang, Changlong |
| 作者单位 | 1.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Solid State Phys, Hefei 230031, Anhui, Peoples R China 2.Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China 3.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab Photovolta & Energy Conservat Mat, Hefei 230031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Jiawei,Hu, Bin,Yang, Liang,et al. Upconversion-based dual-mode optical nanosensor for highly sensitive and colorimetric evaluation of heparin in serum[J]. SENSORS AND ACTUATORS B-CHEMICAL,2021,345. |
| APA | Zhu, Jiawei,Hu, Bin,Yang, Liang,&Jiang, Changlong.(2021).Upconversion-based dual-mode optical nanosensor for highly sensitive and colorimetric evaluation of heparin in serum.SENSORS AND ACTUATORS B-CHEMICAL,345. |
| MLA | Zhu, Jiawei,et al."Upconversion-based dual-mode optical nanosensor for highly sensitive and colorimetric evaluation of heparin in serum".SENSORS AND ACTUATORS B-CHEMICAL 345(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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