Oxygen Vacancy-Driven Reversible Free Radical Catalysis for Environment-Adaptive Cancer Chemodynamic Therapy
文献类型：期刊论文
| 作者 | Yuan, Xi1; Wang, Linlin1; Hu, Miaomiao1; Zhang, Lili1; Chen, Hong1; Zhang, Dailiang1; Wang, Zhimin1; Li, Ting1; Zhong, Minjuan1; Xu, Liujun1 |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2021-08-24 |
| ISSN号 | 1433-7851 |
| 关键词 | cancer-selective catalysis free radicals nanomaterials oxygen vacancies TME modulation |
| DOI | 10.1002/anie.202107556 |
| 通讯作者 | Liu, Yanlan(ylliu@hnu.edu.cn) ; Tan, Weihong(tan@hnu.edu.cn) |
| 英文摘要 | Amplifying free radical production by chemical dynamic catalysis to cause oxidative damage to cancer cells has received extensive interest for cancer-specific therapy. The major challenge is inevitable negative modulation on the tumor microenvironment (TME) by these species, hindering durable effectiveness. Here we show for the first time an oxygen vacancy-rich Bi-based regulator that allows environment-adaptive free radical catalysis. Specifically, the regulator catalyzes production of highly toxic O-2(.-) and (OH)-O-. in cancer cells via logic enzymatic reactions yet scavenges accumulation of free radicals and immunosuppressive mediators in TME-associated noncancerous cells. Atomic-level mechanistic studies reveal that such dual-modal regulating behavior is dominated by oxygen vacancies that well fit for free radical catalytic kinetics, along with distinguished cellular fates of this regulator. With this smart regulator, a "two birds with one shot" cancer dynamic therapy can be expected. |
| WOS关键词 | OXIDATIVE STRESS ; ROS ; INFLAMMATION ; CELLS ; MECHANISMS ; BIOLOGY |
| 资助项目 | National Key R&D Program of China[2020YFA0210802] ; National Natural Science Foundation of China[NSFC21827811] ; National Natural Science Foundation of China[21877031] ; Science and Technology Innovation Program of Hunan Province[2017XK2103] ; Science and Technology Innovation Program of Hunan Province[2018RS3043] ; Young Thousand Talented Program |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000687707200001 |
| 资助机构 | National Key R&D Program of China ; National Natural Science Foundation of China ; Science and Technology Innovation Program of Hunan Province ; Young Thousand Talented Program |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/124431]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Liu, Yanlan; Tan, Weihong |
| 作者单位 | 1.Hunan Univ, Mol Sci & Biomed Lab MBL, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn,Aptamer Engn Ctr Hunan Prov, Changsha 410082, Hunan, Peoples R China 2.Chinese Acad Sci, Univ Chinese Acad Sci, Canc Hosp, Zhejiang Canc Hosp,Inst Basic Med & Canc IBMC, Hangzhou 310022, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Xi,Wang, Linlin,Hu, Miaomiao,et al. Oxygen Vacancy-Driven Reversible Free Radical Catalysis for Environment-Adaptive Cancer Chemodynamic Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2021. |
| APA | Yuan, Xi.,Wang, Linlin.,Hu, Miaomiao.,Zhang, Lili.,Chen, Hong.,...&Tan, Weihong.(2021).Oxygen Vacancy-Driven Reversible Free Radical Catalysis for Environment-Adaptive Cancer Chemodynamic Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION. |
| MLA | Yuan, Xi,et al."Oxygen Vacancy-Driven Reversible Free Radical Catalysis for Environment-Adaptive Cancer Chemodynamic Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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