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CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer

文献类型：期刊论文

作者Wang, Xiaolin1,2,3,4; Li, Jingxin2; Bian, Xing1,2,3,4; Wu, Cheng; Hua, Jinghan1,2,3,4; Chang, Shuhui2; Yu, Tianyi2; Li, Hong1,3,4; Li, Yongxiang5; Hu, Shanshan6
刊名PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
出版日期2021-08-17
卷号118
ISSN号0027-8424
关键词circURI1 cancer metastasis hnRNPM splicing
DOI10.1073/pnas.2012881118
通讯作者Hu, Shanshan(hss923@ustc.edu.cn) ; Shan, Ge(shange@ustc.edu.cn) ; Lin, Wenchu(wenchu@hmfl.ac.cn)
英文摘要Circular RNAs (circRNAs) have emerged as key regulators of human cancers, yet their modes of action in gastric cancer (GC) remain largely unknown. Here, we identified circURI7 back-spliced from exons 3 and 4 of unconventional prefoldin RPB5 interactor 1 (URI1) from circRNA profiling of five-paired human gastric and the corresponding nontu-mor adjacent specimens (paraGC). CircURI7 exhibits the significantly higher expression in GC compared with paraGC and inhibitory effects on cell migration and invasion in vitro and GC metastasis in vivo. Mechanistically, circURI7 directly interacts with heterogeneous nu-clear ribonucleoprotein M (hnRNPM) to modulate alternative splicing of genes, involved in the process of cell migration, thus suppressing GC metastasis. Collectively, our study expands the current knowledge regarding the molecular mechanism of circRNA-mediated cancer me-tastasis via modulating alternative splicing.
WOS关键词LONG NONCODING RNAS ; CIRCULAR RNAS ; UNIQUE FEATURES ; MESSENGER-RNA ; EXPRESSION ; PROTEINS ; ADENOCARCINOMA ; PROLIFERATION ; INVASION ; ABUNDANT
资助项目National Key Research and Development Program of China[2019YFA0802600] ; National Key Research and Development Program of China[2018YFC1004500] ; National Natural Science Foundation of China[81972191] ; National Natural Science Foundation of China[81902525] ; National Natural Science Foundation of China[81672647] ; National Natural Science Foundation of China[31930019] ; National Natural Science Foundation of China[31725016] ; National Natural Science Foundation of China[91940303] ; Science and Technology Major Project of Anhui Province[18030801140] ; Strategic Priority Research Program Biological basis of aging and therapeutic strategies of the Chinese Academy of Sciences[XDB39010400] ; 100-Talent Program of Chinese Academy of Sciences
WOS研究方向Science & Technology - Other Topics
语种英语
出版者NATL ACAD SCIENCES
WOS记录号WOS:000687403700015
资助机构National Key Research and Development Program of China ; National Natural Science Foundation of China ; Science and Technology Major Project of Anhui Province ; Strategic Priority Research Program Biological basis of aging and therapeutic strategies of the Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/124453]  
专题中国科学院合肥物质科学研究院
通讯作者Hu, Shanshan; Shan, Ge; Lin, Wenchu
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Hefei 230031, Peoples R China
2.Univ Sci & Technol China, Hefei 230026, Peoples R China
3.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Peoples R China
4.High Magnet Field Lab Anhui Prov, Hefei 230031, Peoples R China
5.Anhui Med Univ, Affiliated Hosp 1, Dept Gen Surg, Hefei 230022, Peoples R China
6.Univ Sci & Technol China, Div Life Sci & Med, Dept Neurosurg, Hefei 230001, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Xiaolin,Li, Jingxin,Bian, Xing,et al. CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2021,118.
APA Wang, Xiaolin.,Li, Jingxin.,Bian, Xing.,Wu, Cheng.,Hua, Jinghan.,...&Lin, Wenchu.(2021).CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,118.
MLA Wang, Xiaolin,et al."CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 118(2021).

入库方式： OAI收割

来源：合肥物质科学研究院

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