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Super-enhancer-mediated core regulatory circuitry in human cancer

文献类型：期刊论文

作者Jiang, Yuan1,2; Jiang, Yan-Yi1,2; Lin, De-Chen3
刊名COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
出版日期2021
卷号19
ISSN号2001-0370
关键词Super-enhancer Core regulatory circuitry Transcription factor Transcriptional dysregulation Human cancer
DOI10.1016/j.csbj.2021.05.006
通讯作者Jiang, Yan-Yi(yanyij@cmpt.ac.cn) ; Lin, De-Chen(De-Chen.Lin@cshs.org)
英文摘要Super-enhancers (SEs) are congregated enhancer clusters with high level of loading of transcription factors (TFs), cofactors and epigenetic modifications. Through direct co-occupancy at their own SEs as well as each other's, a small set of so called "master" TFs form interconnected core regulatory circuitry (CRCs) to orchestrate transcriptional programs in both normal and malignant cells. These master TFs can be predicted mathematically using epigenomic methods. In this Review, we summarize the identification of SEs and CRCs in cancer cells, the mechanisms by which master TFs and SEs cooperatively regulate cancer type-specific expression programs, and the cancer-type- and subtype-specificity of CRC and the significance in cancer biology. (C) 2021 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.
WOS关键词CELL IDENTITY ; TRANSCRIPTION FACTORS ; SELECTIVE-INHIBITION ; HISTONE DEACETYLASES ; SIGNALING PATHWAYS ; REVEAL ; P63 ; DIFFERENTIATION ; NEUROBLASTOMA ; HETEROGENEITY
资助项目Cedars-Sinai Cancer Project Acceleration Fund ; Transla-tional Oncology Program Discovery Fund ; DeGregorio Family Foundation ; Esophageal Cancer Awareness Association ; Savone Family
WOS研究方向Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
语种英语
出版者ELSEVIER
WOS记录号WOS:000684856500013
资助机构Cedars-Sinai Cancer Project Acceleration Fund ; Transla-tional Oncology Program Discovery Fund ; DeGregorio Family Foundation ; Esophageal Cancer Awareness Association ; Savone Family
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/124456]  
专题中国科学院合肥物质科学研究院
通讯作者Jiang, Yan-Yi; Lin, De-Chen
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Hlth & Med Technol, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China
2.Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China
3.Cedars Sinai Med Ctr, Dept Med, 8700 Beverly Blvd, Los Angeles, CA 90048 USA
推荐引用方式
GB/T 7714		 Jiang, Yuan,Jiang, Yan-Yi,Lin, De-Chen. Super-enhancer-mediated core regulatory circuitry in human cancer[J]. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL,2021,19.
APA Jiang, Yuan,Jiang, Yan-Yi,&Lin, De-Chen.(2021).Super-enhancer-mediated core regulatory circuitry in human cancer.COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL,19.
MLA Jiang, Yuan,et al."Super-enhancer-mediated core regulatory circuitry in human cancer".COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL 19(2021).

入库方式： OAI收割

来源：合肥物质科学研究院

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