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Evidence-based meta-analysis of the genotoxicity induced by microplastics in aquatic organisms at environmentally relevant concentrations

文献类型：期刊论文

作者Sun, Tao1,4; Zhan, Junfei1,4; Li, Fei2,4; Ji, Chenglong2,3,4; Wu, Huifeng2,3,4
刊名SCIENCE OF THE TOTAL ENVIRONMENT
出版日期2021-08-20
卷号783页码:9
关键词Microplastics Aquatic organisms Genotoxicity Meta-analysis Environmentally relevant concentrations
ISSN号0048-9697
DOI10.1016/j.scitotenv.2021.147076
通讯作者Wu, Huifeng(hfwu@yic.ac.cn)
英文摘要Microplastics (MPs) attract global concern due to their ubiquitous existence in aquatic environments. However, the genotoxic effect of MPs on aquatic organisms in the natural environment remains controversial. Therefore, this meta-analysis was conducted by recompiling 44 individual studies from 12 publications to determine whether MPs could induce genotoxicity in aquatic organisms at environmentally relevant concentrations (<= 1 mg/L, median = 0.5 mg/L). Multiple genotoxic endpoints were involved, including the percentage of DNA in tail (TDNA%), tail length (TL), olive tail moment (OTM), and the number of micronuclei (NM), and their increases represented the biologically adverse effects (i.e. genotoxicity). The results showed that all included endpoints tended to increase after exposure to MPs, among which TDNA%, TL and NM were significantly increased by 20%, 32% and 81% compared with the control group, respectively. The overall estimate of all endpoints in the MPs-treated groups was remarkably increased by 24%, with high statistical power and no obvious publication bias, suggesting the evident genotoxicity caused by MPs. In addition, the magnitudes of MPs-induced genotoxicity were independent of selected endpoint, MP composition, morphology, exposure concentration and duration, but closely correlated with particle size, living habitat and tested species. Overall, this work provided a reference for the health risk assessment of MPs in the natural environment, contributing to our understanding the action mode of MPs at environmentally relevant concentrations.& nbsp; (c) 2021 Elsevier B.V. All rights reserved.
WOS关键词MARINE-ENVIRONMENT ; POLYSTYRENE MICROPLASTICS ; MYTILUS SPP. ; EXPOSURE ; NANOPLASTICS ; FRAGMENTATION ; CONTAMINANTS ; RESPONSES ; IMPACT ; LEAD
资助项目National Natural Science Foundation of China[42076164] ; Young Taishan Scholars Program of Shandong Province[tsqn201812115]
WOS研究方向Environmental Sciences & Ecology
语种英语
WOS记录号WOS:000656998400016
资助机构National Natural Science Foundation of China ; Young Taishan Scholars Program of Shandong Province
源URL[http://ir.yic.ac.cn/handle/133337/29385]  
专题烟台海岸带研究所_近岸生态与环境实验室
烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
通讯作者Wu, Huifeng
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China
4.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc,YICCAS, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Tao,Zhan, Junfei,Li, Fei,et al. Evidence-based meta-analysis of the genotoxicity induced by microplastics in aquatic organisms at environmentally relevant concentrations[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2021,783:9.
APA Sun, Tao,Zhan, Junfei,Li, Fei,Ji, Chenglong,&Wu, Huifeng.(2021).Evidence-based meta-analysis of the genotoxicity induced by microplastics in aquatic organisms at environmentally relevant concentrations.SCIENCE OF THE TOTAL ENVIRONMENT,783,9.
MLA Sun, Tao,et al."Evidence-based meta-analysis of the genotoxicity induced by microplastics in aquatic organisms at environmentally relevant concentrations".SCIENCE OF THE TOTAL ENVIRONMENT 783(2021):9.

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来源：烟台海岸带研究所

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