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Evaluation of cyclooxygenase-2 fluctuation via a near-infrared fluorescent probe in idiopathic pulmonary fibrosis cell and mice models

文献类型：期刊论文

作者Wang, Yude3,4,5; Wei, Yinghui4,5; He, Na2; Zhang, Liangwei3; You, Jinmao1; Chen, Lingxin1,3; Lv, Changjun4,5
刊名JOURNAL OF MATERIALS CHEMISTRY B
出版日期2021-07-10
页码8
ISSN号2050-750X
DOI10.1039/d1tb01307f
通讯作者Zhang, Liangwei(liangweizhang@yic.ac.cn) ; Chen, Lingxin(lxchen@yic.ac.cn) ; Lv, Changjun(lucky_lcj@sina.com)
英文摘要Idiopathic pulmonary fibrosis (IPF) is a devastating and fatal interstitial lung disease due to various challenges in diagnosis and treatment. Due to its complicated pathogenesis and difficulty in early diagnosis, there is no effective cure. Cyclooxygenase-2 (COX-2) is inextricably associated with pulmonary fibrosis. The abnormal level of COX-2 leads to extremely exacerbated pulmonary fibrosis. Therefore, we reported a near-infrared fluorescent probe Cy-COX to detect the fluctuation of COX-2 levels during pulmonary fibrosis and explain its important protective effect. The probe Cy-COX showed a significant enhancement of fluorescence signal to COX-2 with excellent selectivity and sensitivity. In order to clarify the relationship between COX-2 and pulmonary fibrosis, we used the probe Cy-COX to detect COX-2 fluctuation in organisms with pulmonary fibrosis. The results showed that the COX-2 level increased in the early stage and decreased in the late stage with the aggravation of pulmonary fibrosis. Furthermore, up-regulation of COX-2 levels can effectively alleviate the severity of pulmonary fibrosis. Therefore, Cy-COX is a fast and convenient imaging tool with great potential to predict the early stage of pulmonary fibrosis and evaluate the therapeutic effects.
WOS关键词INTERSTITIAL LUNG-DISEASE ; CANCER ; COX-2 ; FIBROBLASTS ; PATHOGENESIS ; INFLAMMATION ; EXPRESSION
资助项目National Natural Science Foundation of China[81573393] ; National Natural Science Foundation of China[21804010] ; National Natural Science Foundation of China[21976209] ; National Natural Science Foundation of China[21976105] ; National Natural Science Foundation of China[81870001] ; National Natural Science Foundation of China[21778026] ; science and technology innovation development plan of Yantai of China[2020MSGY113] ; Research Initiation Fund of Binzhou Medical University[BY2019KYQD39] ; Research Initiation Fund of Binzhou Medical University[BY2020KYQD01] ; Taishan Scholar Project Special Funding[ts20190962]
WOS研究方向Materials Science
语种英语
WOS记录号WOS:000678242600001
资助机构National Natural Science Foundation of China ; science and technology innovation development plan of Yantai of China ; Research Initiation Fund of Binzhou Medical University ; Taishan Scholar Project Special Funding
源URL[http://ir.yic.ac.cn/handle/133337/29548]  
专题烟台海岸带研究所_山东省海岸带环境工程技术研究中心
烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
通讯作者Zhang, Liangwei; Chen, Lingxin; Lv, Changjun
作者单位1.Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Key Lab Pharmaceut Intermediates & Anal Nat Med, Qufu 273165, Shandong, Peoples R China
2.Shandong Univ, Cheelo Coll Med, Qilu Hosp, Rehabil Ctr, Jinan 250100, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Key Lab Coastal Environm Proc, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
4.Binzhou Med Univ, Inst Mol Med, Med Res Ctr, Yantai 264003, Peoples R China
5.Binzhou Med Univ Hosp, Dept Resp Med, Binzhou 256603, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Yude,Wei, Yinghui,He, Na,et al. Evaluation of cyclooxygenase-2 fluctuation via a near-infrared fluorescent probe in idiopathic pulmonary fibrosis cell and mice models[J]. JOURNAL OF MATERIALS CHEMISTRY B,2021:8.
APA Wang, Yude.,Wei, Yinghui.,He, Na.,Zhang, Liangwei.,You, Jinmao.,...&Lv, Changjun.(2021).Evaluation of cyclooxygenase-2 fluctuation via a near-infrared fluorescent probe in idiopathic pulmonary fibrosis cell and mice models.JOURNAL OF MATERIALS CHEMISTRY B,8.
MLA Wang, Yude,et al."Evaluation of cyclooxygenase-2 fluctuation via a near-infrared fluorescent probe in idiopathic pulmonary fibrosis cell and mice models".JOURNAL OF MATERIALS CHEMISTRY B (2021):8.

入库方式： OAI收割

来源：烟台海岸带研究所

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