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Modification of carboxymethyl inulin with heterocyclic compounds: Synthesis, characterization, antioxidant and antifungal activities

文献类型：期刊论文

作者Mi, Yingqi2,3,4; Zhang, Jingjing3,4; Han, Xiangru1; Tan, Wenqiang3,4; Miao, Qin2,3,4; Cui, Jingmin2,3,4; Li, Qing3,4; Guo, Zhanyong2,3,4
刊名INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
出版日期2021-06-30
卷号181页码:572-581
关键词Carboxymethyl inulin Antioxidant Heterocyclic moieties
ISSN号0141-8130
DOI10.1016/j.ijbiomac.2021.03.109
通讯作者Guo, Zhanyong(zhanyongguo@hotmail.com)
英文摘要A series of novel inulin derivatives were designed and synthesized by the introduction of amino heterocyclic moieties onto carboxymethyl inulin with the aid of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hyd roxysucci ni mide. The target products were prepared via three - step chemical synthesis, and structures were identified by FTIR and H-1 NMR spectroscopy. Antioxidant activities of inulin derivatives including DPPH - radical scavenging assay, superoxide - radical scavenging assay, hydroxyl - radical scavenging assay, and reducing power were estimated. Meanwhile, their antifungal activities, including Colletotrichum lagenarium and Bottytis cinerea, were also explored by hyphal measurement. In particular, inulin derivatives bearing heterocyclic moieties exhibited a remarkable improvement over inulin on antioxidant and antifungal activities, and their bioactivities decreased roughly in the order of 2ATCMI > 4APCMI > 3APCMI > 2APCMI > 3ATCMI > CMI > inulin. Furthermore, the cytotoxicities of inulin derivatives against L929 cells were evaluated by CCK-8 in vitro, and all samples showed weak cytotoxicities. In a nutshell, the paper provides a practical approach to synthesize novel inulin derivatives with dramatically enhanced bioactivity and good biocompatibility. The product described in paper might serve as a new leading structure for further design of antioxidants or antifungal agents in biomedicine, cosmetics, and other fields. (C) 2021 Elsevier B.V. All rights reserved.
WOS关键词IN-VITRO ; DERIVATIVES ; PREDICTION ; CHITOSANS
资助项目National Key Research and Development Program of China[2019YFD1002704-01] ; Natural Science Foundation of Shandong Province of China[ZR2019BD064]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种英语
WOS记录号WOS:000656891400007
资助机构National Key Research and Development Program of China ; Natural Science Foundation of Shandong Province of China
源URL[http://ir.yic.ac.cn/handle/133337/29382]  
专题烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
海岸带生物资源高效利用研究与发展中心
通讯作者Guo, Zhanyong
作者单位1.Yantai Univ, Coll Environm & Mat Engn, Yantai 264005, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China
4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714		 Mi, Yingqi,Zhang, Jingjing,Han, Xiangru,et al. Modification of carboxymethyl inulin with heterocyclic compounds: Synthesis, characterization, antioxidant and antifungal activities[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2021,181:572-581.
APA Mi, Yingqi.,Zhang, Jingjing.,Han, Xiangru.,Tan, Wenqiang.,Miao, Qin.,...&Guo, Zhanyong.(2021).Modification of carboxymethyl inulin with heterocyclic compounds: Synthesis, characterization, antioxidant and antifungal activities.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,181,572-581.
MLA Mi, Yingqi,et al."Modification of carboxymethyl inulin with heterocyclic compounds: Synthesis, characterization, antioxidant and antifungal activities".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 181(2021):572-581.

入库方式： OAI收割

来源：烟台海岸带研究所

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